Synthesis of 1-tetralones by intramolecular Friedel-Crafts reaction of 4-arylbutyric acids using Lewis acid catalysts

被引：71

作者：

Cui, DM ^{[1
]}

Kawamura, M ^{[1
]}

Shimada, S ^{[1
]}

Hayashi, T ^{[1
]}

Tanaka, M ^{[1
]}

机构：

[1] AIST, Natl Inst Adv Ind Sci & Technol, Tsukuba, Ibaraki 3058565, Japan

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 21期

关键词：

tetralone; Lewis acid; Friedel-Crafts reaction; bismuth; cyclization;

D O I：

10.1016/S0040-4039(03)00855-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Intramolecular Friedel-Crafts reaction of 4-arylbutyric acids efficiently proceeded in the presence of catalytic amounts of Lewis acids such as Bi(NTf2)(3) and M(OTf)(3) (M = Bi, Ga, In and rare-earth metals) to form 1-tetralones. Chroman-4-one and thiochroman-4-one were also obtained in good yields front 3-phenoxypropionic acid and 3-phenylthiopropionic acid, respectively. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：4007 / 4010

页数：4

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