Cytotoxic triterpenoids from Ganoderma lucidum

被引：162

作者：

Cheng, Chun-Ru ^{[1
]}

Yue, Qing-Xi ^{[1
]}

Wu, Zhi-Yuan ^{[1
]}

Song, Xiao-Yi ^{[1
]}

Tao, Si-Jia ^{[1
]}

Wu, Xiao-Hui ^{[1
]}

Xu, Ping-Ping ^{[1
]}

Liu, Xuan ^{[1
]}

Guan, Shu-Hong ^{[1
]}

Guo, De-An ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Natl Engn Lab TCM Standardizat Technol, Shanghai Inst Mat Med,Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China

来源：

PHYTOCHEMISTRY | 2010年 / 71卷 / 13期

基金：

中国国家自然科学基金;

关键词：

Ganoderma lucidum; Triterpenoids; Cytotoxicity; Structure and activity relationship; TUMOR-CELL-LINES; FR KARST; ACID-F; INHIBITORY TRITERPENES; GANOLUCIDIC ACID; CONSTITUENTS; LANOSTANOIDS; TERPENOIDS; METABOLITES; BITTERNESS;

D O I：

10.1016/j.phytochem.2010.06.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

A systematic study of the metabolites in Ganoderma lucidum led to isolation of 43 triterpenoids, six of them (1-6) are hitherto unknown. The structures of the latter were elucidated on the basis of spectroscopic studies and comparison with the known related compounds. All of the compounds were assayed for their inhibitory activities against human HeLa cervical cancer cell lines. Some compounds exhibit significant cytotoxicity, and their structure-activity relationships are discussed. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1579 / 1585

页数：7

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