A wide role for NOTCH1 signaling in acute leukemia

被引：60

作者：

Chiaramonte, R

Basile, A

Tassi, E

Calzavara, E

Cecchinato, V

Rossi, V

Biondi, A

Comi, P

机构：

[1] Univ Milan, Dept Biomed Sci & Technol, I-20090 Milan, Italy

[2] Univ Milan, S Gerardo Hosp, Ctr M Tettamanti, Pediat Clin, Monza, Italy

来源：

CANCER LETTERS | 2005年 / 219卷 / 01期

关键词：

NOTCH1; JAGGED1; T-ALL; BCP-ALL; AML;

D O I：

10.1016/j.canlet.2004.07.022

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

NOTCH1 is involved in the pathogenesis of T-acute lymphoblastic leukemia (T-ALL) carrying the very rare translocation t(7;9)(q34;q34.3). We analyzed the expression of genes belonging to NOTCH pathway, in acute leukemia primary samples and lymphoblastoid cell lines. NOTCH1 pathway activation represents a common feature of T-ALL when compared to acute myelogenous leukemia (AML) and B-cell precursor acute lymphoblastic leukemia. The contemporary expression of NOTCH1 and its ligands on cell surface contributes to high levels of pathway activity. AML primary samples show high levels of JAGGED1 expression despite the low NOTCH1 pathway activation, consistent with an autonomous JAGGED1 signaling in myeloid leukemogenesis. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

收藏

页码：113 / 120

页数：8

相关论文

共 26 条

[1] The C-terminal PDZ-ligand of JAGGED1 is essential for cellular transformation [J].

Ascano, JM ;

Beverly, LJ ;

Capobianco, AJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (10) :8771-8779

[2] Perturbation of lkaros isoform selection by MLV integration is a cooperative event in NotchIC-induced T cell leukemogenesis [J].

Beverly, LJ ;

Capobianco, AJ .

CANCER CELL, 2003, 3 (06) :551-564

[3] Differential regulation of notch signal transduction in leukaemia and lymphoma cells in culture [J].

Chiaramonte, R ;

Calzavara, E ;

Balordi, F ;

Sabbadini, M ;

Capello, D ;

Gaidano, G ;

Serra, A ;

Comi, P ;

Sherbet, GV .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2003, 88 (03) :569-577

[4] Characterization of the transcriptional expression of Notch-1 signaling pathway members, Deltex and HES-1, in developing mouse thymocytes [J].

Choi, JW ;

Pampeno, C ;

Vukmanovic, S ;

Meruelo, D .

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2002, 26 (06) :575-588

[5]

CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2

[6] Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes [J].

Deftos, ML ;

Huang, E ;

Ojala, EW ;

Forbush, KA ;

Bevan, MJ .

IMMUNITY, 2000, 13 (01) :73-84

[7] TAN-1, THE HUMAN HOMOLOG OF THE DROSOPHILA NOTCH GENE, IS BROKEN BY CHROMOSOMAL TRANSLOCATIONS IN T-LYMPHOBLASTIC NEOPLASMS [J].

ELLISEN, LW ;

BIRD, J ;

WEST, DC ;

SORENG, AL ;

REYNOLDS, TC ;

SMITH, SD ;

SKLAR, J .

CELL, 1991, 66 (04) :649-661

[8] Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia [J].

Ferrando, AA ;

Neuberg, DS ;

Staunton, J ;

Loh, ML ;

Huard, C ;

Raimondi, SC ;

Behm, FG ;

Pui, CH ;

Downing, JR ;

Gilliland, DG ;

Lander, ES ;

Golub, TR ;

Look, AT .

CANCER CELL, 2002, 1 (01) :75-87

[9] Modulated expression of NOTCH1 during thymocyte development [J].

Hasserjian, RP ;

Aster, JC ;

Davi, F ;

Weinberg, DS ;

Sklar, J .

BLOOD, 1996, 88 (03) :970-976

[10] Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength [J].

Izon, DJ ;

Punt, JA ;

Xu, LW ;

Karnell, FG ;

Allman, D ;

Myung, PS ;

Boerth, NJ ;

Pui, JC ;

Koretzky, GA ;

Pear, WS .

IMMUNITY, 2001, 14 (03) :253-264