Current research on the immunomodulatory effect of allogeneic blood transfusion

被引：59

作者：

Dzik, S

Blajchman, MA

Blumberg, N

Kirkley, SA

Heal, JM

Wood, K

机构：

[1] HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA

[2] MCMASTER UNIV,DEPT PATHOL,HAMILTON,ON,CANADA

[3] MCMASTER UNIV,DEPT MED,HAMILTON,ON,CANADA

[4] CANADIAN RED CROSS SOC,HAMILTON CTR,HAMILTON,ON,CANADA

[5] UNIV ROCHESTER,DEPT PATHOL & LAB MED,TRANSFUS MED UNIT,ROCHESTER,NY

[6] UNIV ROCHESTER,DEPT PATHOL & LAB MED,HEMATOL UNIT,ROCHESTER,NY

[7] UNIV ROCHESTER,DEPT MED,ROCHESTER,NY

[8] AMER RED CROSS,BLOOD SERV,NEW YORK PENN REG,ROCHESTER,NY

[9] UNIV OXFORD,JOHN RADCLIFFE HOSP,NUFFIELD DEPT SURG,OXFORD OX3 9DU,ENGLAND

来源：

VOX SANGUINIS | 1996年 / 70卷 / 04期

关键词：

D O I：

10.1111/j.1423-0410.1996.tb01324.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This review summarizes three aspects of current research on the immunomodulatory effect of allogeneic transfusion, Representatives of three laboratories each of which is actively engaged in research on transfusion-induced immunomodulation - summarize their current investigative approach, First, current animal models of transfusion-induced immunomodulation are presented and research on the tumor growth-promoting effect of allogeneic transfusion is described. Second, mechanisms underlying an immunomodulatory effect of transfusion are summarized and experiments on the induction of transplant tolerance by selective introduction of donor-type MHC antigens is presented. Third, - the potential clinical impact of increased infection and tumor recurrence resulting from transfusion-induced immunomodulation is assessed. The potential role of donor-derived hematopoietic stem cells is presented as an area of future investigation in the area of transfusion-induced immunomodulation.

引用

页码：187 / 194

页数：8

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