Airway remodeling in asthma

被引：151

作者：

Halwani, Rabih ^{[1
,3
]}

Al-Muhsen, Saleh ^{[1
,2
,3
]}

Hamid, Qutayba ^{[1
,3
,4
]}

机构：

[1] King Saud Univ, Asthma Res Chair, Riyadh, Saudi Arabia

[2] King Saud Univ, Coll Med, Dept Pediat, Riyadh 11461, Saudi Arabia

[3] King Saud Univ, Prince Naif Ctr Immunol Res, Riyadh, Saudi Arabia

[4] McGill Univ, Meakins Christie Labs, Montreal, PQ, Canada

来源：

CURRENT OPINION IN PHARMACOLOGY | 2010年 / 10卷 / 03期

关键词：

SMOOTH-MUSCLE-CELLS; OBSTRUCTIVE PULMONARY-DISEASE; ENDOTHELIAL GROWTH-FACTOR; REGULATORY T-CELLS; HUMAN BRONCHIAL FIBROBLASTS; EPITHELIAL-CELLS; ANIMAL-MODELS; SUBEPITHELIAL FIBROSIS; COLLAGEN DEPOSITION; ALLERGEN CHALLENGE;

D O I：

10.1016/j.coph.2010.06.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Asthmatic airway remodeling is the pathophysiological modifications of the normal airway wall structure which include changes in the composition and organization of its cellular and molecular constituents. These modifications are the major cause of the symptoms associated with decreased pulmonary function. Airway remodeling is partially reversible in mild asthma but mostly irreversible in chronic severe asthma. It is initiated as a repair process in response to airway wall injuries caused by inflammation; however, dysregulation of this process leads to airway remodeling. In this review, we will summarize the most recent findings about the different structural changes in airways of asthmatics as well as mediators involved in this process.

引用

收藏

页码：236 / 245

页数：10

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