Results of magnetic resonance imaging in long-term manganese dioxide-exposed workers

被引:69
作者
Dietz, MC [1 ]
Ihrig, A
Wrazidlo, W
Bader, M
Jansen, O
Triebig, G
机构
[1] Univ Heidelberg Hosp, Inst & Polyclin Occupat & Social Med, Heidelberg, Germany
[2] Atos Outpatients Clin, Heidelberg, Germany
[3] Univ Heidelberg Hosp, Dept Neuroradiol, Heidelberg, Germany
关键词
neurotoxicity; manganese; occupational exposure; biomonitoring; magnetic resonance imaging;
D O I
10.1006/enrs.2000.4068
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Within a cross-sectional study, the neurotoxic effects of occupational exposure to manganese were examined. From a group of 90 (58 male and 32 female) workers, 11 men with long-term and high exposure to manganese dioxide (MnO2) dust were defined as exposed workers. Eleven age-matched workers of similar socioeconomic status were used as a reference group. Ambient air and biological monitoring (blood, urine, hair), clinical (Webster Rating Scale, WRS), neurophysiological (visual evoked potentials (VEP), nerve conduction velocity (NCV), electroencephalography (EEG)), and motor performance (Wiener Testsystem) examinations were performed. The pallidal index (PI), the ratio of globus pallidus to subcortical frontal white-matter signal intensity in T-1-weighted magnetic resonance imaging (MRI) planes multiplied by 100, was used. For the individual body burden, manganese in blood was the most reliable bio marker. A "job exposure matrix" for the cumulative Mn-exposure index (CEI) was calculated for each worker. The results of WRS, VEP, NCV, EEG, and motor performance tests showed no significant group differences. However, the pallidal index was increased in Mn-exposed persons. Furthermore, a statistically significant positive correlation was found between CEI and pallidal index. The results of other studies are discussed. The meaning of MRI findings for health status as well as gender-specific differences should be examined in further follow-up studies. (C) 2000 Academic Press.
引用
收藏
页码:37 / 40
页数:4
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