Antigastric autoantibodies in ferrets naturally infected with Helicobacter mustelae

被引：16

作者：

Cróinín, TO

Clyne, M ^{[1
]}

Appelmelk, BJ

Drumm, B

机构：

[1] Univ Coll Dublin, Our Ladys Hosp Sick Children, Childrens Res Ctr, Dept Paediat, Dublin 12, Ireland

[2] Univ Coll Dublin, Conway Inst Mol & Biomed Res, Dept Pediat, Dublin 2, Ireland

[3] Vrije Univ Amsterdam, Dept Med Microbiol, Amsterdam, Netherlands

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 04期

关键词：

D O I：

10.1128/IAI.69.4.2708-2713.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Infection with Helicobacter pylori has been associated with induction of autoantibodies that cross-react with the gastric mucosa. There have been discordant reports as to whether or not these autoantibodies arise due to molecular mimicry between H. pylori and host cell antigens on parietal cells. In this study, we investigated whether molecular mimicry by H. mustelae causes autoantibodies in infected ferrets. Serum from H, mustelae-infected ferrets reacted with parietal cells in the ferret gastric mucosa but not with duodenal or colonic mucosa. These sera did not react with the blood group A epitope on erythrocytes or H. mustelae lipopolysaccharide, and absorption with H. mustelae whole cells or red blood cells did not remove autoantibodies. In conclusion, ferrets naturally infected with H. mustelae generate antibodies that react with parietal cells, but these autoantibodies are not due to molecular mimicry.

引用

页码：2708 / 2713

页数：6

共 30 条

[1] Reactivities of Lewis antigen monoclonal antibodies with the lipopolysaccharides of Helicobacter pylori strains isolated from patients with gastroduodenal diseases in Japan [J].