Megazol combined with suramin: a chemotherapy regimen which reversed the CNS pathology in a model of human African trypanosomiasis in mice

被引:33
作者
Enanga, B
Keita, M
Chauviere, G
Dumas, M
Bouteille, B
机构
[1] Fac Med Limoges, Inst Epidemiol Neurol & Neurol Trop, F-87025 Limoges, France
[2] Univ Toulouse 3, Grp Chim Organ Biol, F-31062 Toulouse, France
关键词
megazol; suramin; CNS-trypanosomiasis;
D O I
10.1046/j.1365-3156.1998.00291.x
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Chemotherapy for human African trypanosomiasis (HAT), or sleeping sickness, is unreliable because of resistance, refraction and toxic and adverse side-effects. Using a long-term experimental model of HAT with involvement of the central nervous system (CNS), we tested the ability of a megazol and suramin combination treatment to eliminate CNS trypanosomes. This consisted of 20 mg suramin per kg body weight administered intraperitoneally (IP), followed 24 h later by 4 daily doses (80 mg/kg) of megazol given either IP or per os. One week post-treatment, neurological disorders had disappeared. One of 15 mice relapsed in each application group at 81 and 98 days after treatment, respectively Bt six months, no signs of relapse were seen in remaining mice, indicating that this chemotherapy regimen was curative. Immunohistochemical (astrocytosis) and histological (inflammatory lesions) examinations of brain tissues showed that animals returned to normal from 2 months post-treatment. These results suggest that the megazol-suramin combination reversed the CNS pathology in this model.
引用
收藏
页码:736 / 741
页数:6
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