A heady message for lifespan regulation

被引：11

作者：

Cowen, T ^{[1
]}

机构：

[1] UCL Royal Free & Univ Coll Med Sch, Dept Anat & Dev Biol, London NW3 2PF, England

来源：

TRENDS IN GENETICS | 2001年 / 17卷 / 03期

关键词：

D O I：

10.1016/S0168-9525(00)02214-9

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Mutant Caenorhabditis elegans in which the age-1 and daf-2 genes (involved in insulin-receptor-like signalling) are expressed at low levels exhibit extended lifespan. Wolkow and colleagues recently showed that restricted re-expression of age-1 and daf-2 genes in neurons of these mutants rescues wild-type lifespan as effectively as ubiquitous re-expression. Low levels of insulin-like signalling in neurons might control longevity by enhancing protection against free radical damage. However, in mammalian cells (including neurons) reduced insulin-like signalling is generally thought to be deleterious to antioxidant defence and to neuron survival. Here we discuss the new work and several hypotheses to explain this apparent contradiction.

引用

页码：109 / 113

页数：5

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