Tumour micro environment -: Opinion -: Emerging roles of proteases in tumour suppression

被引：606

作者：

LOpez-Otin, Carlos ^{[1
]}

Matrisian, Lynn M.

机构：

[1] Univ Oviedo, Fac Med, Inst Univ Oviedo, Dept Bioquim & Biol Mol, E-33006 Oviedo, Spain

[2] Vanderbilt Univ, Dept Canc Biol, Nashville, TN 37232 USA

来源：

NATURE REVIEWS CANCER | 2007年 / 7卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrc2228

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Proteases have long been associated with cancer progression because of their ability to degrade extracellular matrices, which facilitates invasion and metastasis. However, recent studies have shown that these enzymes target a diversity of substrates and favour all steps of tumour evolution. Unexpectedly, the post- trial studies have also revealed proteases with tumour- suppressive effects. These effects are associated with more than 30 different enzymes that belong to three distinct protease classes. What are the clinical implications of these findings?

引用

页码：800 / 808

页数：9

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