Iron availability affects entry of Listeria monocytogenes into the enterocytelike cell line Caco-2

被引：42

作者：

Conte, MP ^{[1
]}

Longhi, C ^{[1
]}

Polidoro, M ^{[1
]}

Petrone, G ^{[1
]}

Buonfiglio, V ^{[1
]}

DiSanto, S ^{[1
]}

Papi, E ^{[1
]}

Seganti, L ^{[1
]}

Visca, P ^{[1
]}

Valenti, P ^{[1
]}

机构：

[1] UNIV NAPLES 2,INST MICROBIOL,NAPLES,ITALY

来源：

INFECTION AND IMMUNITY | 1996年 / 64卷 / 09期

关键词：

D O I：

10.1128/IAI.64.9.3925-3929.1996

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The influence of iron on the entry of Listeria monocytogenes into Caco-2 cells was studied. Iron availability was found to modify the surface hydrophobicity and protein profile of L. monocytogenes, with the result that cell invasion strongly increased upon bacterial growth in iron-rich medium. The enhanced invasive capability of iron-overloaded L. monocytogenes cells correlates to the higher-level expression of the inlAB virulence genes, which were positively iron regulated at the transcriptional level.

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页码：3925 / 3929

页数：5

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