Insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBP-1, -2 and -3) in diabetic pregnancy: Relationship to macrosomia

被引:39
作者
Liu, YJ
Tsushima, T
Minei, S
Sanaka, M
Nagashima, T
Yanagisawa, K
Omori, Y
机构
[1] TOKYO WOMENS MED COLL,DEPT MED 3,CTR DIABET,TOKYO 162,JAPAN
[2] TOKYO WOMENS MED COLL,DEPT MED 2,INST CLIN ENDOCRINOL,TOKYO 162,JAPAN
关键词
diabetic pregnancy; macrosomia; insulin-like growth factor-I; -II; (IGF-I; IGF-II); insulin-like growth factor-binding proteins (IGFBP-1; -2; -3);
D O I
10.1507/endocrj.43.221
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
To evaluate the role of insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) in exessive fetal growth (macrosomia) in diabetic pregnancy, 84 insulin-treated diabetic mothers and their infants were tested for serum concentrations of IGF-I, IFG-II, and IGFBP-1, -2 and -3. These parameters were correlated with the birth weight of neonates and placental weight. IGF-I and II levels were determined by specific radioimmunoassays (RIAs) after serum samples were extracted with aid-ethanol. IGFBPs were measured by Western immunoblot with specific antibodies to the respective IGFBP species. Serum concentrations of both IGF-I and IGF-II in mothers with either IDDM or NIDDM increased with the gestational period, reached a plateau at the third trimester, and returned to non-pregnant levels within 7 days after delivery. These values were not different from those in normal mothers before and throughout pregnancy. As previously reported, IGF-I concentrations in cord serum of neonates born to diabetic mothers were (P<0.01) higher than those of newborns of normal mothers. Likewise, cord blood IGF-II levels were 2-fold higher in babies of diabetic mothers (P<0.001). Fetal IGF-I and IGF-II correlated with each other and with maternal HbA1c, and they positively correlated with either birth weight or placental weight. Cord IGFBP-3 concentrations were significantly higher in diabetic pregnancy, but IGFBP-2 concentrations were not different from those in normal pregnancy. Cord IGFBP-1 concentrations were significantly higher only in babies of mothers with IDDM. None of these cord IGFBP concentrations correlated with birth weight or placental weight. The data suggest that fetal IGF-II, like IGF-I, is involved in fetal and placental growth in diabetic pregnancy. The role of IGFBPs remained to be determined.
引用
收藏
页码:221 / 231
页数:11
相关论文
共 46 条
[1]  
ASAKAWA K, 1990, ENDOCRINOL JAPON, V37, P607
[2]   INSULIN-LIKE GROWTH-FACTORS (IGF)-1 AND (IGF)-2 IN HUMAN-FETAL PLASMA AND RELATIONSHIP TO GESTATIONAL-AGE AND FETAL SIZE DURING MIDPREGNANCY [J].
ASHTON, IK ;
ZAPF, J ;
EINSCHENK, I ;
MACKENZIE, IZ .
ACTA ENDOCRINOLOGICA, 1985, 110 (04) :558-563
[3]  
BAKER J, 1993, CELL, V75, P73, DOI 10.1016/0092-8674(93)90680-O
[4]   LEVELS OF INSULIN-LIKE GROWTH FACTOR-I AND FACTOR-II IN HUMAN CORD BLOOD [J].
BENNETT, A ;
WILSON, DM ;
LIU, F ;
NAGASHIMA, R ;
ROSENFELD, RG ;
HINTZ, RL .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1983, 57 (03) :609-612
[5]   EFFECT OF INSULIN ON THE HEPATIC PRODUCTION OF INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-1 (IGFBP-1), IGFBP-3, AND IGF-I IN INSULIN-DEPENDENT DIABETES [J].
BRISMAR, K ;
FERNQVISTFORBES, E ;
WAHREN, J ;
HALL, K .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1994, 79 (03) :872-878
[6]   INSULIN-LIKE GROWTH FACTOR-I (IGF-I) INFUSION INTO HYPOPHYSECTOMIZED OR PROTEIN-DEPRIVED RATS INDUCES SPECIFIC IGF-BINDING PROTEINS IN SERUM [J].
CLEMMONS, DR ;
THISSEN, JP ;
MAES, M ;
KETELSLEGERS, JM ;
UNDERWOOD, LE .
ENDOCRINOLOGY, 1989, 125 (06) :2967-2972
[7]   VARIABLES CONTROLLING THE SECRETION OF INSULIN-LIKE GROWTH-FACTOR BINDING PROTEIN-2 IN NORMAL HUMAN-SUBJECTS [J].
CLEMMONS, DR ;
SNYDER, DK ;
BUSBY, WH .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1991, 73 (04) :727-733
[8]  
CRYSTAL RA, 1991, MODERN CONCEPTS INSU, P395
[9]   MEASUREMENT OF SOMATOMEDIN-RELATED PEPTIDES IN FETAL, NEONATAL, AND MATERNAL RAT SERUM BY INSULIN-LIKE GROWTH-FACTOR (IGF)-I RADIOIMMUNOASSAY, IGF-II RADIORECEPTOR ASSAY (RRA), AND MULTIPLICATION-STIMULATING ACTIVITY RRA AFTER ACID-ETHANOL EXTRACTION [J].
DAUGHADAY, WH ;
PARKER, KA ;
BOROWSKY, S ;
TRIVEDI, B ;
KAPADIA, M .
ENDOCRINOLOGY, 1982, 110 (02) :575-581
[10]   A GROWTH-DEFICIENCY PHENOTYPE IN HETEROZYGOUS MICE CARRYING AN INSULIN-LIKE GROWTH FACTOR-II GENE DISRUPTED BY TARGETING [J].
DECHIARA, TM ;
EFSTRATIADIS, A ;
ROBERTSON, EJ .
NATURE, 1990, 345 (6270) :78-80