Chemical synthesis of GDP-L-galactose and analogues

被引：43

作者：

Binch, H ^{[1
]}

Stangier, K ^{[1
]}

Thiem, J ^{[1
]}

机构：

[1] Univ Hamburg, Inst Organ Chem, D-20146 Hamburg, Germany

来源：

CARBOHYDRATE RESEARCH | 1998年 / 306卷 / 03期

关键词：

L-galactono-1,4-lactone; GDP-beta-L-galactose and analogues; 3-deoxy-L-galactose; 3,6-dideoxy-L-galactose;

D O I：

10.1016/S0008-6215(97)10094-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Succinct syntheses for L-galactose, 3-deoxy-L-xylo-hexose (3-deoxy-L-galactose), 6-deoxy-L-galactopyranose (L-fucose) and 3,6-dideoxy-L-xylo-hexose (3,6-dideoxy-L-galactose) have been developed starting from commercially available L-galactono-1,4-lactone. L-Galactose and variants were then converted to the guanosine diphosphate derivatives, via the formation of the anomeric phosphates and coupling to guanosine monophosphate morpholidate. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：409 / 419

页数：11

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