Hepatic stem cells: From bone marrow cells to hepatocytes

被引：35

作者：

Mitaka, T ^{[1
]}

机构：

[1] Sapporo Med Univ, Sch Med, Canc Res Inst, Dept Pathol,Chuo Ku, Sapporo, Hokkaido 0608556, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2001年 / 281卷 / 01期

关键词：

hepatic stem cell; hematopoietic stem cell; oval cell; small hepatocyte; differentiation; maturation;

D O I：

10.1006/bbrc.2001.4270

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hematopoiesis and the hepatic environment are known to have a close relationship at the time of hepatic development and systemic diseases. Recently, transplanted cells isolated from bone marrow of rodents and humans have been shown to differentiate into oval cells, which are considered to be hepatic stem cells, and hepatocytes in the liver. Then, purified hematopoietic stem cells were shown to have the ability to replace original liver cells in mice with hereditary tyrosinemia. In this review the interactions between hepatic stem cells are summarized and a hypothesis of hepatic differentiation will be proposed. (C) 2001 Academic Press.

引用

页码：1 / 5

页数：5

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