Ca2+/CREB/CBP-dependent gene regulation:: a shared mechanism critical in long-term synaptic plasticity and neuronal survival

被引：116

作者：

Bito, H ^{[1
]}

Takemoto-Kimura, S

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Neurochem, Bunkyo Ku, Tokyo 1130033, Japan

[2] Japan Sci & Technol Corp, PRESTO, Bunkyo Ku, Tokyo 1130033, Japan

[3] Kyoto Univ, Fac Med, Dept Pharmacol, Sakyo Ku, Kyoto 6068315, Japan

来源：

CELL CALCIUM | 2003年 / 34卷 / 4-5期

关键词：

gene regulation; synaptic plasticity; neuronal survival; calcium; CREB; CBP; CaM kinase;

D O I：

10.1016/S0143-4160(03)00140-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

CREB is a transcription factor critical for long-term synaptic plasticity. Intriguingly, recent work has elucidated a role for CREB, as well as upstream CREB kinases, in the control of activity-dependent neuronal survival. Additionally, analysis of the molecular pathology of polyglutamine-repeat diseases suggest that alteration of pCREB-CBP function may underlie, at least in part, the neurodegenerative process. Taken together, these new findings support the idea that Ca2+/CREB/CBP-dependent gene regulation might be a shared mechanism critical in both long-term synaptic plasticity and neuronal survival. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：425 / 430

页数：6

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