Structure and Mechanisms of Lysine Methylation Recognition by the Chromodomain in Gene Transcription

被引：88

作者：

Yap, Kyoko L. ^{[1
]}

Zhou, Ming-Ming ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Dept Struct & Chem Biol, New York, NY 10065 USA

来源：

BIOCHEMISTRY | 2011年 / 50卷 / 12期

基金：

美国国家卫生研究院;

关键词：

HISTONE H3 METHYLATION; RNA-POLYMERASE-II; HETEROCHROMATIN PROTEIN-1 HP1; DOSAGE COMPENSATION COMPLEX; POLYCOMB-GROUP PROTEINS; EMBRYONIC STEM-CELLS; DNA-BINDING PROTEIN; SACCHAROMYCES-CEREVISIAE; DROSOPHILA-MELANOGASTER; MSL3; CHROMODOMAIN;

D O I：

10.1021/bi101885m

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Histone methylation recognition is accomplished by a number of evolutionarily conserved protein domains, including those belonging to the methylated lysine-binding Royal family of structural folds. One well-known member of the Royal family, the chromodomain, is found in the HP1/chromobox and CHD subfamilies of proteins, in addition to a small number of other proteins that are involved in chromatin remodeling and gene transcriptional silencing. Here we discuss the structure and function of the chromodomain within these proteins as methylated histone lysine binders and how the functions of these chromodomains can be modulated by additional, post-translational modifications or binding to nucleic acids.

引用

页码：1966 / 1980

页数：15

共 139 条

[1] Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31 [J].

Aagaard, L ;

Laible, G ;

Selenko, P ;

Schmid, M ;

Dorn, R ;

Schotta, G ;

Kuhfittig, S ;

Wolf, A ;

Lebersorger, A ;

Singh, PB ;

Reuter, G ;

Jenuwein, T .

EMBO JOURNAL, 1999, 18 (07) :1923-1938

[2] Chromodomains are protein-RNA interaction modules [J].

Akhtar, A ;

Zink, D ;

Becker, PB .

NATURE, 2000, 407 (6802) :405-409

[3] Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer [J].

Andersen, C. L. ;

Christensen, L. L. ;

Thorsen, K. ;

Schepeler, T. ;

Sorensen, F. B. ;

Verspaget, H. W. ;

Simon, R. ;

Kruhoffer, M. ;

Aaltonen, L. A. ;

Laurberg, S. ;

Orntoft, T. F. .

BRITISH JOURNAL OF CANCER, 2009, 100 (03) :511-523

[4] HP1-β mobilization promotes chromatin changes that initiate the DNA damage response [J].

Ayoub, Nabieh ;

Jeyasekharan, Anand D. ;

Bernal, Juan A. ;

Venkitaraman, Ashok R. .

NATURE, 2008, 453 (7195) :682-U14

[5] Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation [J].

Ayyanathan, K ;

Lechner, MS ;

Bell, P ;

Maul, GG ;

Schultz, DC ;

Yamada, Y ;

Tanaka, K ;

Torigoe, K ;

Rauscher, FJ .

GENES & DEVELOPMENT, 2003, 17 (15) :1855-1869

[6] CHD5 is a tumor suppressor at human 1p36 [J].

Bagchi, Anindya ;

Papazoglu, Cristian ;

Wu, Ying ;

Capurso, Daniel ;

Brodt, Michael ;

Francis, Dailia ;

Bredel, Markus ;

Vogel, Hannes ;

Mills, Alea A. .

CELL, 2007, 128 (03) :459-475

[7] CHD7 cooperates with PBAF to control multipotent neural crest formation [J].

Bajpai, Ruchi ;

Chen, Denise A. ;

Rada-Iglesias, Alvaro ;

Zhang, Junmei ;

Xiong, Yiqin ;

Helms, Jill ;

Chang, Ching-Pin ;

Zhao, Yingming ;

Swigut, Tomek ;

Wysocka, Joanna .

NATURE, 2010, 463 (7283) :958-U135

[8] Structure of the chromatin binding (chromo) domain from mouse modifier protein 1 [J].

Ball, LJ ;

Murzina, NV ;

Broadhurst, RW ;

Raine, ARC ;

Archer, SJ ;

Stott, FJ ;

Murzin, AG ;

Singh, PB ;

Domaille, PJ ;

Laue, ED .

EMBO JOURNAL, 1997, 16 (09) :2473-2481

[9] Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain [J].

Bannister, AJ ;

Zegerman, P ;

Partridge, JF ;

Miska, EA ;

Thomas, JO ;

Allshire, RC ;

Kouzarides, T .

NATURE, 2001, 410 (6824) :120-124

[10] High-resolution profiling of histone methylations in the human genome [J].

Barski, Artern ;

Cuddapah, Suresh ;

Cui, Kairong ;

Roh, Tae-Young ;

Schones, Dustin E. ;

Wang, Zhibin ;

Wei, Gang ;

Chepelev, Iouri ;

Zhao, Keji .

CELL, 2007, 129 (04) :823-837

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