Haem oxygenase-I and cardiovascular disease: mechanisms and therapeutic potential

被引:52
作者
Chan, Kim H. [3 ,4 ]
Ng, Martin K. C. [3 ,4 ]
Stocker, Roland [1 ,2 ]
机构
[1] Univ Sydney, Sch Med Sci Pathol, Sydney, NSW 2006, Australia
[2] Univ Sydney, Bosch Inst, Sydney, NSW 2006, Australia
[3] Heart Res Inst, Newtown, NSW 2042, Australia
[4] Royal Prince Alfred Hosp, Dept Cardiol, Camperdown, NSW 2050, Australia
基金
英国医学研究理事会;
关键词
angiogenesis; atherosclerosis; bilirubin; cardiovascular disease; haem oxygenase-1 (HO-1); vascular repair; CORONARY-ARTERY-DISEASE; GENE PROMOTER POLYMORPHISM; SOLUBLE GUANYLATE-CYCLASE; MUSCLE-CELL PROLIFERATION; HUMAN ENDOTHELIAL-CELLS; GROWTH-FACTOR SYNTHESIS; CARBON-MONOXIDE; NITRIC-OXIDE; OXIDATIVE STRESS; SERUM BILIRUBIN;
D O I
10.1042/CS20100508
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Cardiovascular disease remains the leading cause of death worldwide. Despite progress in management, there remain a significant number of patients who are not eligible for current treatment options. Traditionally, HO-1 (haem oxygenase-1), one of two isoenzymes that initiate haem catabolism, was thought to only play a metabolic role. However, HO-I is now recognized to have additional protective activities in states of heightened noxious stimuli or stress such as acute coronary syndromes. The present review article provides an overview of the mode of action of HO-I in vascular protection, with particular emphasis on its atheroprotective, anti-inflammatory and antioxidative properties, as well as its role in vascular repair. Furthermore, we present evidence for the protective effects of HO-I in CVD (cardiovascular disease) in both animal and human studies. Given its potential in vascular protection and repair, strategies aimed at inducing HO-I emerge as a novel and alternative therapeutic target in the management of CVD.
引用
收藏
页码:493 / 504
页数:12
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