Immobilization of kojic acid in ZnAl-hydrotalcite like compounds

被引：19

作者：

Ambrogi, Valeria ^{[1
]}

Perioli, Luana ^{[1
]}

Nocchetti, Morena ^{[2
]}

Latterini, Loredana ^{[3
]}

Pagano, Cinzia ^{[1
]}

Massetti, Elena ^{[1
]}

Rossi, Carlo ^{[1
]}

机构：

[1] Univ Perugia, Dipartimento Chim & Tecnol Farmaco, I-06123 Perugia, Italy

[2] Univ Perugia, Dipartimento Chim, I-06123 Perugia, Italy

[3] Univ Perugia, CEMIN Dipartimento Chim, I-06123 Perugia, Italy

来源：

JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS | 2012年 / 73卷 / 01期

关键词：

Inorganic compounds; Chemical synthesis; Infrared spectroscopy; Thermogravimetric analysis; X-ray diffraction; ANIONIC CLAYS; PHOTOSTABILITY; PHOTOPROTECTION; RELEASE; HEALTH; ZINC;

D O I：

10.1016/j.jpcs.2011.10.007

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Kojic acid (KOJ) is a melanin synthesis inhibitor widely used as skin lightening agent in topical preparations. Unfortunately it is easily susceptible to photo-oxidation, phenomenon responsible for chemical and organoleptic modifications. The aim of this work was the intercalation of KOJ in hydrotalcite-like compounds (HTlc) in order to stabilize KOJ and to reduce its photolability. Hydrotalcite containing Zn and Al (ZnAl-HTlc) was used as host to obtain the final compound ZnAl-HTlc-KOJ. The intercalation was carried out, after many attempts, by ionic exchange mechanism by means of the strong base EtO- in anhydrous ethanol/dimethylsulfoxide (DMSO) mixture as solvent in order to generate KOJ(-) anions. The final product was characterized by the X-ray powder diffraction (XRPD), FT-IR spectroscopy, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and elemental analysis. The intercalated compound was formulated in a siliconic water free self-emulsifying ointment and the in vitro release profile was evaluated. All samples (intercalation compound and its formulation) were submitted also to spectrophotometric assays in order to evaluate the matrix protective effect towards ultraviolet rays. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：94 / 98

页数：5

共 24 条

[1]

Effect of hydrotalcite-like compounds on the aqueous solubility of some poorly water-soluble drugs [J].