Protective effects of selenomethionine against cisplatin-induced renal toxicity in mice and rats

被引:28
作者
Rao, M [1 ]
Rao, MNA [1 ]
机构
[1] Coll Pharmaceut Sci, Dept Pharmaceut Chem, Manipal 576119, Karnataka, India
关键词
D O I
10.1111/j.2042-7158.1998.tb06906.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The effect of selenomethionine on the toxicity of cisplatin has been studied in mice and rats. When selenomethionine (0.5-4 mg kg(-1)) was administered intraperitoneally to mice 1 h before intraperitoneal cisplatin (6 mg kg(-1)), the toxicity of cisplatin, as measured by loss of body weight and blood urea nitrogen and serum creatinine levels, was reduced significantly. The protection was dose-dependent but less when given orally. Similar results were obtained with rats. Deterioration of renal function was characterized by reduced creatinine clearance, and increased excretion of urinary protein was significantly reversed. Partial but significant protection was also observed against capsulation-induced reduction of white blood-cell count. Protective properties were further demonstrated by increased survival of mice pretreated with selenomethionine compared with the lethality observed for animals given cisplatin only. These results suggested that selenomethionine protects against cisplatin-induced renal and other toxicity. The study has many clinical implications in cancer chemotherapy and needs further investigation.
引用
收藏
页码:687 / 691
页数:5
相关论文
共 25 条
[1]  
[Anonymous], 1980, METAL IONS BIOL SYST
[2]  
Badmaev V, 1996, Altern Ther Health Med, V2, P59
[3]  
BALDEW GS, 1989, CANCER RES, V49, P3020
[4]  
BERRY JP, 1983, CANCER RES, V44, P2854
[5]   Attenuation of oxidation and nitration reactions of peroxynitrite by selenomethionine, selenocystine and ebselen [J].
Briviba, K ;
Roussyn, I ;
Sharov, VS ;
Sies, H .
BIOCHEMICAL JOURNAL, 1996, 319 :13-15
[6]  
BULL JMC, 1988, CANCER RES, V48, P2239
[7]  
ELFERINK F, 1986, CLIN CHEM, V32, P641
[8]  
GODKAR PB, 1994, TXB MED LAB TECHNOLO
[9]   THE NEPHROTOXICITY OF CISPLATIN [J].
GOLDSTEIN, RS ;
MAYOR, GH .
LIFE SCIENCES, 1983, 32 (07) :685-690
[10]   FACTORS INFLUENCING THE INHIBITORY EFFECT OF SELENIUM ON MICE INOCULATED WITH EHRLICH ASCITES TUMOR-CELLS [J].
GREEDER, GA ;
MILNER, JA .
SCIENCE, 1980, 209 (4458) :825-827