Blockade of K-ATP channels with glibenclamide does not abolish preconditioning during demand ischemia

被引：27

作者：

Correa, SD

Schaefer, S

机构：

[1] Division of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA

[2] Div. of Cardiovasc. Medicine, TB 172, University of California, Davis

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 1997年 / 79卷 / 01期

关键词：

D O I：

10.1016/S0002-9149(96)00681-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The role of adenosine triphosphate-sensitive potassium channels in the adaptive response to demand ischemia was tested in 22 patients treated with placebo or glibenclamide before sequential exercise testing or atrial pacing, Glibenclamide did not affect the improvement in signs of ischemia in both protocols, indicating that opening of these channels is not a mechanism of this adaptive response in humans.

引用

页码：75 / &

页数：5

共 18 条

[1] CARMELIET E, 1990, CARDIAC ELECTROPHYSI, P103
[2] ADAPTATION TO ISCHEMIA DURING PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY - CLINICAL, HEMODYNAMIC, AND METABOLIC FEATURES
DEUTSCH, E
BERGER, M
KUSSMAUL, WG
HIRSHFELD, JW
HERRMANN, HC
LASKEY, WK
[J]. CIRCULATION, 1990, 82 (06) : 2044 - 2051
[3] ACTIVATION OF CARDIAC ATP-SENSITIVE K+ CURRENT DURING HYPOXIA - CORRELATION WITH TISSUE ATP LEVELS
DEUTSCH, N
KLITZNER, TS
LAMP, ST
WEISS, JN
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 261 (03): : H671 - H676
[4] GLIBENCLAMIDE DOES NOT ABOLISH THE PROTECTIVE EFFECT OF PRECONDITIONING ON STUNNING IN THE ISOLATED PERFUSED RAT-HEART
FRALIX, TA
STEENBERGEN, C
LONDON, RE
MURPHY, E
[J]. CARDIOVASCULAR RESEARCH, 1993, 27 (04) : 630 - 637
[5] KLIMT CR, 1970, DIABETES, V19, P747
[6] DOES ISCHEMIC PRECONDITIONING OCCUR IN PATIENTS
KLONER, RA
YELLON, D
[J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1994, 24 (04) : 1133 - 1142
[7] Rapid ventricular pacing produces myocardial protection by nonischemic activation of K-ATP(+) channels
Koning, MMG
Gho, BCG
vanKlaarwater, E
Opstal, RLJ
Duncker, DJ
Verdouw, PD
[J]. CIRCULATION, 1996, 93 (01) : 178 - 186
[8] COMPARISON OF MYOCARDIAL ATP, BLOOD-FLOW, AND CYTOSOLIC ADENOSINE IN DEMAND ISCHEMIA AND CORONARY-OCCLUSION
KROLL, K
MARTIN, GV
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1995, 269 (03): : H819 - H828
[9] PROTECTION AGAINST INFARCTION AFFORDED BY PRECONDITIONING IS MEDIATED BY A1 ADENOSINE RECEPTORS IN RABBIT HEART
LIU, GS
THORNTON, J
VANWINKLE, DM
STANLEY, AWH
OLSSON, RA
DOWNEY, JM
[J]. CIRCULATION, 1991, 84 (01) : 350 - 356
[10] MYOCARDIAL-METABOLISM DURING INCREASED WORK STATES IN THE PORCINE LEFT-VENTRICLE IN-VIVO
MASSIE, BM
SCHWARTZ, GG
GARCIA, J
WISNESKI, JA
WEINER, MW
OWENS, T
[J]. CIRCULATION RESEARCH, 1994, 74 (01) : 64 - 73

← 1 2 →