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Innate immunity in higher insects

被引：296
作者：
Hoffmann, JA
Reichhart, JM
Hetru, C
机构：
[1] Inst. de Biol. Molec. et Cellulaire, CNRS, 67084 Strasbourg Cedex
来源：
CURRENT OPINION IN IMMUNOLOGY | 1996年 / 8卷 / 01期
关键词：
D O I：
10.1016/S0952-7915(96)80098-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The hallmark of the innate immune response of higher insects is the rapid and transient synthesis of a battery of broad spectrum antimicrobial peptides by the fat body. The control of the genes encoding these peptides involves cis-regulatory promoter elements homologous to sequences functional in mammalian acute-phase genes. Study of immune-deficient mutants of Drosophila has indicated that distinct pathways control the antibacterial and antifungal responses in this species. Novel receptors potentially involved in the initiation of the immune response have been recently characterized.
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页码：8 / 13
页数：6
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