A chemoselective, acid mediated conversion of amide acetal to oxazole: The key step in the synthesis of cardiovascular drug, ifetroban sodium.

被引：11

作者：

Swaminathan, S ^{[1
]}

Singh, AK

Li, WS

Venit, JJ

Natalie, KJ

Simpson, JH

Weaver, RE

Silverberg, LJ

机构：

[1] Bristol Myers Squibb, Chem Proc Technol, New Brunswick, NJ 08903 USA

[2] Bristol Myers Squibb, Tech Operat, Syracuse, NY 13221 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 27期

关键词：

D O I：

10.1016/S0040-4039(98)00904-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cyclization of acetal amide was carried out with trimethylsilyl trifluoromethanesulfonate, followed by elimination using sodium methoxide to give 2,5-disubstituted oxazole, thus completing a new route to the cardivascular drug ifetroban sodium. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：4769 / 4772

页数：4

共 14 条

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