Turnover of lymphocytes and conceptual paradigms in HIV infection

被引:102
作者
Silvestri, G
Feinberg, MB
机构
[1] Emory Vaccine Ctr, Atlanta, GA 30329 USA
[2] Emory Univ, Sch Med, Atlanta, GA 30322 USA
关键词
T-CELL DEPLETION; ACTIVATION; DYNAMICS; VIRUS; CD4; PATHOGENESIS; APOPTOSIS;
D O I
10.1172/JCI200319799
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Prevailing views concerning the pathogenic mechanisms of AIDS have shifted from models that focus primarily on direct HIV-mediated killing of CD4(+) T cells to models that emphasize the pathogenic role of generalized immune system activation. The observation that increases in T cell turnover seen in HIV-infected individuals primarily reflect increased proliferation of effector-memory T cells (see the related article beginning on page 956) supports the concept that chronic immune activation plays a prominent, if not predominant, role in the pathogenesis of AIDS.
引用
收藏
页码:821 / 824
页数:4
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