cerebellum;
hippocampus;
long-term potentiation;
motor learning;
D O I:
10.1046/j.0953-816x.2001.01486.x
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
To elucidate the role of the N-methyl-D-aspartate (NMDA) - type glutamate receptor subunit epsilon1 (GluR epsilon1) in classical eyeblink conditioning, delay and trace eyeblink conditioning were investigated in GluR epsilon1-null mutant mice. In delay conditioning and short-trace interval conditioning with a trace interval of 250 ms, GluR epsilon1 mutant mice attained a normal level of the conditioned response (CR), although acquisition was a little slower than in wild-type mice. In contrast, GluR epsilon1 mutant mice exhibited severe impairment of the attained level of the CR and disturbed temporal pattern of CR expression in trace conditioning with a longer trace interval of 500 ms. These findings indicate that GluR epsilon1 is essential for long-trace interval eyeblink conditioning. The impairments of the associative learning with a long temporal separation between the conditioned and unconditioned stimuli observed in the GluR epsilon1 mutant mice could be attributed to an impairment of hippocampal long-term potentiation in this line of mutant mice.
机构:MIT, Howard Hughes Med Inst, Ctr Learning & Memory, Dept Biol, Cambridge, MA 02139 USA
Huerta, PT
Sun, LD
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机构:MIT, Howard Hughes Med Inst, Ctr Learning & Memory, Dept Biol, Cambridge, MA 02139 USA
Sun, LD
Wilson, MA
论文数: 0引用数: 0
h-index: 0
机构:MIT, Howard Hughes Med Inst, Ctr Learning & Memory, Dept Biol, Cambridge, MA 02139 USA
Wilson, MA
Tonegawa, S
论文数: 0引用数: 0
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机构:
MIT, Howard Hughes Med Inst, Ctr Learning & Memory, Dept Biol, Cambridge, MA 02139 USAMIT, Howard Hughes Med Inst, Ctr Learning & Memory, Dept Biol, Cambridge, MA 02139 USA
机构:MIT, Howard Hughes Med Inst, Ctr Learning & Memory, Dept Biol, Cambridge, MA 02139 USA
Huerta, PT
Sun, LD
论文数: 0引用数: 0
h-index: 0
机构:MIT, Howard Hughes Med Inst, Ctr Learning & Memory, Dept Biol, Cambridge, MA 02139 USA
Sun, LD
Wilson, MA
论文数: 0引用数: 0
h-index: 0
机构:MIT, Howard Hughes Med Inst, Ctr Learning & Memory, Dept Biol, Cambridge, MA 02139 USA
Wilson, MA
Tonegawa, S
论文数: 0引用数: 0
h-index: 0
机构:
MIT, Howard Hughes Med Inst, Ctr Learning & Memory, Dept Biol, Cambridge, MA 02139 USAMIT, Howard Hughes Med Inst, Ctr Learning & Memory, Dept Biol, Cambridge, MA 02139 USA