Long-trace interval eyeblink conditioning is impaired in mutant mice lacking the NMDA receptor subunit ε1

被引:39
作者
Kishimoto, Y
Kawahara, S
Mori, H
Mishina, M
Kirino, Y
机构
[1] Univ Tokyo, Sch Pharmaceut Sci, Lab Neurobiophys, Bunkyo Ku, Tokyo 1130033, Japan
[2] Japan Sci & Technol Corp, CREST, Saitama 3320012, Japan
[3] Univ Tokyo, Sch Med, Dept Mol Neurobiol & Pharmacol, Tokyo 1130033, Japan
关键词
cerebellum; hippocampus; long-term potentiation; motor learning;
D O I
10.1046/j.0953-816x.2001.01486.x
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
To elucidate the role of the N-methyl-D-aspartate (NMDA) - type glutamate receptor subunit epsilon1 (GluR epsilon1) in classical eyeblink conditioning, delay and trace eyeblink conditioning were investigated in GluR epsilon1-null mutant mice. In delay conditioning and short-trace interval conditioning with a trace interval of 250 ms, GluR epsilon1 mutant mice attained a normal level of the conditioned response (CR), although acquisition was a little slower than in wild-type mice. In contrast, GluR epsilon1 mutant mice exhibited severe impairment of the attained level of the CR and disturbed temporal pattern of CR expression in trace conditioning with a longer trace interval of 500 ms. These findings indicate that GluR epsilon1 is essential for long-trace interval eyeblink conditioning. The impairments of the associative learning with a long temporal separation between the conditioned and unconditioned stimuli observed in the GluR epsilon1 mutant mice could be attributed to an impairment of hippocampal long-term potentiation in this line of mutant mice.
引用
收藏
页码:1221 / 1227
页数:7
相关论文
共 41 条
  • [1] REDUCED HIPPOCAMPAL LONG-TERM POTENTIATION AND CONTEXT-SPECIFIC DEFICIT IN ASSOCIATIVE LEARNING IN MGLUR1 MUTANT MICE
    AIBA, A
    CHEN, C
    HERRUP, K
    ROSENMUND, C
    STEVENS, CF
    TONEGAWA, S
    [J]. CELL, 1994, 79 (02) : 365 - 375
  • [2] Bao SW, 1998, LEARN MEMORY, V5, P355
  • [3] Microinjections of anisomycin into the intermediate cerebellum during learning affect the acquisition of classically conditioned responses in the rabbit
    Bracha, V
    Irwin, KB
    Webster, ML
    Wunderlich, DA
    Stachowiak, MK
    Bloedel, JR
    [J]. BRAIN RESEARCH, 1998, 788 (1-2) : 169 - 178
  • [4] Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC gamma mutant mice
    Chen, C
    Kano, M
    Abeliovich, A
    Chen, L
    Bao, SW
    Kim, JJ
    Hashimoto, K
    Thompson, RF
    Tonegawa, S
    [J]. CELL, 1995, 83 (07) : 1233 - 1242
  • [5] Chen L, 1996, J NEUROSCI, V16, P2829
  • [6] Bilateral lesions of the interpositus nucleus completely prevent eyeblink conditioning in Purkinje cell-degeneration mutant mice
    Chen, L
    Bao, SW
    Thompson, RF
    [J]. BEHAVIORAL NEUROSCIENCE, 1999, 113 (01) : 204 - 210
  • [7] Classical conditioning and brain systems: The role of awareness
    Clark, RE
    Squire, LR
    [J]. SCIENCE, 1998, 280 (5360) : 77 - 81
  • [8] AGE-RELATED DISRUPTION OF TRACE BUT NOT DELAY CLASSICAL-CONDITIONING OF THE RABBITS NICTITATING-MEMBRANE RESPONSE
    GRAVES, CA
    SOLOMON, PR
    [J]. BEHAVIORAL NEUROSCIENCE, 1985, 99 (01) : 88 - 96
  • [9] CLONED GLUTAMATE RECEPTORS
    HOLLMANN, M
    HEINEMANN, S
    [J]. ANNUAL REVIEW OF NEUROSCIENCE, 1994, 17 : 31 - 108
  • [10] Formation of temporal memory requires NMDA receptors within CA1 pyramidal neurons
    Huerta, PT
    Sun, LD
    Wilson, MA
    Tonegawa, S
    [J]. NEURON, 2000, 25 (02) : 473 - 480