Therapeutic applications of mesenchymal stromal cells

被引：221

作者：

Brooke, Gary ^{[1
]}

Cooka, Matthew ^{[1
]}

Blair, Chris ^{[2
]}

Han, Rachel ^{[1
]}

Heazlewood, Celena ^{[1
]}

Jones, Ben ^{[3
]}

Kambouris, Melinda ^{[4
]}

Kollar, Kate ^{[1
]}

McTaggart, Steven ^{[3
]}

Pelekanos, Rebecca ^{[1
]}

Rice, Alison ^{[4
]}

Rossetti, Tony ^{[1
]}

Atkinson, Kerry ^{[1
,5
]}

机构：

[1] Mater Med Res Inst, Biotherapy Program, Adult Stem Cell Lab, Brisbane, Qld 4101, Australia

[2] St Vincents Hosp, Victor Chang Cardiac Res Ctr, Sydney, NSW 2010, Australia

[3] Mater Med Res Inst, Biotherapy Program, Solid Organ Transplant Lab, Brisbane, Qld 4101, Australia

[4] Mater Med Res Inst, Biotherapy Program, Bone Marrow Transplant Lab, Brisbane, Qld 4101, Australia

[5] Univ Queensland, Brisbane, Qld, Australia

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2007年 / 18卷 / 06期

关键词：

mesenchymal stromal cells; mesenchymal stem cells; therapeutic applications; review;

D O I：

10.1016/j.semcdb.2007.09.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mesenchymal stromal cells (MSC) are multipotent cells that can be derived from many different organs and tissues. They have been demonstrated to play a role in tissue repair and regeneration in both preclinical and clinical studies. They also have remarkable immunosuppressive properties. We describe their application in settings that include the cardiovascular, central nervous, gastrointestinal, renal, orthopaedic and haematopoietic systems. Manufacturing of MSC for clinical trials is also discussed. Since tissue matching between MSC donor and recipient does not appear to be required, MSC may be the first cell type able to be used as an "off-the-shelf" therapeutic product. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：846 / 858

页数：13

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