Risk factors for melanoma by body site for whites

被引:102
作者
Cho, EY
Rosner, BA
Colditz, GA
机构
[1] Harvard Univ, Sch Med, Dept Med, Channing Lab, Boston, MA 02115 USA
[2] Brigham & Womens Hosp, Boston, MA 02115 USA
[3] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA
[4] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
[5] Harvard Univ, Ctr Canc Prevent, Boston, MA 02115 USA
关键词
D O I
10.1158/1055-9965.EPI-04-0632
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
It has been hypothesized that cutaneous melanoma at different anatomic sites develops through divergent pathways. We examined this hypothesis prospectively. We followed 152,949 women and 25,204 men free of cancer at baseline for up to 14 years in three large prospective studies. We examined risk factors for melanoma by anatomic location (head or neck, trunk, upper extremity, and lower extremity). Polytomous logistic regression was used to test the difference among risk factors by location of melanoma. A total of 511 incident cases of invasive melanoma (49 head or neck, 188 trunk, 98 upper extremity, and 176 lower extremity) were included in the analysis. Compared with females, males had a higher risk of developing melanoma on the head or neck and trunk. History of severe and painful sunburn was most strongly related to melanoma of upper extremity; individuals with > 10 burns had a 6.86-fold (95% confidence interval, 2.62-18.00) higher risk of melanoma of upper extremity compared with those with no burns (P for trend < 0.0001; P for difference by body site = 0.04). Number of moles was most strongly related to melanoma of the trunk; the multivariate relative risk for having > 10 moles was 4.67 (95% confidence interval, 3.07-7.11) compared with having no moles (P for trend < 0.0001; P for difference by body site = 0.04). Age, family history of melanoma, and hair color did not statistically differ by anatomic site of the cancer. These data support divergent etiologic pathways of melanoma development by anatomic sites.
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页码:1241 / 1244
页数:4
相关论文
共 26 条
[1]   SELF-REPORTS OF MOLE COUNTS AND CUTANEOUS MALIGNANT-MELANOMA IN WOMEN - METHODOLOGICAL ISSUES AND RISK OF DISEASE [J].
BAIN, C ;
COLDITZ, GA ;
WILLETT, WC ;
STAMPFER, MJ ;
GREEN, A ;
BRONSTEIN, BR ;
MIHM, MC ;
ROSNER, B ;
HENNEKENS, CH ;
SPEIZER, FE .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1988, 127 (04) :703-712
[2]  
Bataille V, 1998, INT J CANCER, V78, P8, DOI 10.1002/(SICI)1097-0215(19980925)78:1<8::AID-IJC2>3.0.CO
[3]  
2-U
[4]  
Chen YT, 1996, INT J CANCER, V67, P636, DOI 10.1002/(SICI)1097-0215(19960904)67:5<636::AID-IJC8>3.0.CO
[5]  
2-V
[6]  
CHO E, 2005, IN PRESS J CLIN ONCO
[7]  
CRESS RD, 1995, CANCER EPIDEM BIOMAR, V4, P831
[8]   DISTRIBUTION OF MALIGNANT-MELANOMA ON THE BODY-SURFACE [J].
CROMBIE, IK .
BRITISH JOURNAL OF CANCER, 1981, 43 (06) :842-849
[9]   COMPARISON OF BASELINE AND REPEATED MEASURE COVARIATE TECHNIQUES IN THE FRAMINGHAM HEART-STUDY [J].
CUPPLES, LA ;
DAGOSTINO, RB ;
ANDERSON, K ;
KANNEL, WB .
STATISTICS IN MEDICINE, 1988, 7 (1-2) :205-218
[10]   RELATION OF POOLED LOGISTIC-REGRESSION TO TIME-DEPENDENT COX REGRESSION-ANALYSIS - THE FRAMINGHAM HEART-STUDY [J].
DAGOSTINO, RB ;
LEE, ML ;
BELANGER, AJ ;
CUPPLES, LA ;
ANDERSON, K ;
KANNEL, WB .
STATISTICS IN MEDICINE, 1990, 9 (12) :1501-1515