Carbonylation. 6. Regioselective synthesis of 3-phenylpropionic acid and derivatives by catalytic carbonylation of benzylic substrates

被引：3

作者：

Bonnet, MC ^{[1
]}

Monteiro, AL ^{[1
]}

Tkatchenko, I ^{[1
]}

机构：

[1] CNRS, Chim Coordinat Lab, F-31077 Toulouse, France

来源：

COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE II FASCICULE C-CHIMIE | 1998年 / 1卷 / 10期

关键词：

alkoxycarbonylation; palladium; proton co-catalyst; 1-phenylethyl propionate; 3-phenylpropionic derivatives; 1-phenylethyl methyl ether;

D O I：

10.1016/S1387-1609(99)80014-0

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Catalytic carbonylation of benzylic eaters, ethers or alcohols in the presence of [Pd(PPh3)(2)Cl-2] and HBF4. OEt2 as co-catalyst affords 3-phenylpropionic acid or eaters with good yields and selectivities. It is shown that the reaction proceeds smoothly in methanol through the intermediary of the corresponding l-phenylethyl methyl ether. (C) Academie des sciences/Elsevier, Paris.

引用

收藏

页码：603 / 607

页数：5

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