Minocycline-induced DRESS: Evidence for accumulation of the culprit drug

Background: Minocycline-induced drug rash with eosinophilia and systemic symptoms ( DRESS) may have a prolonged course, especially in African and African-American patients. Objectives: To determine if a prolonged course of minocycline-induced DRESS was associated with an accumulation of the culprit drug. Patients and Methods: We determined plasma and skin levels of minocycline in patients with minocycline-induced DRESS. We investigated the genetic polymorphisms of enzymes potentially involved in the detoxification of the drug, glutathione S-transferases and UDP-glucuronosyltransferases. Results and Conclusions: We demonstrated the persistence of minocycline in the plasma and/or in the skin of 7 out of 9 patients with skin photo-types V-VI. As pigmented skin contains more melanin, this could promote the formation of a melanin-minocycline complex, which could explain the severe and prolonged DRESS which may occur in this subgroup of patients. Copyright (c) 2008 S. Karger AG, Basel.