Molecular Pathogenesis of Hepatocellular Carcinoma

被引：40

作者：

Cornella, Helena ^{[1
]}

Alsinet, Clara ^{[1
]}

Villanueva, Augusto ^{[1
]}

机构：

[1] CIBERehd, IDIBAPS, HCC Translat Res Lab, BCLC Grp,Liver Unit,Hosp Clin, Barcelona 08036, Catalonia, Spain

来源：

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH | 2011年 / 35卷 / 05期

关键词：

Hepatocellular Carcinoma; Signaling Pathways; Genomics; Molecular Targeted Therapies; Prognosis Prediction; GENE-EXPRESSION; EARLY RECURRENCE; PREDICTION; HEPATITIS; ALCOHOL; CLASSIFICATION; ACTIVATION; PROGNOSIS; SIGNATURE; PATHWAYS;

D O I：

10.1111/j.1530-0277.2010.01406.x

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Hepatocellular carcinoma (HCC) is one of the major causes of death among cirrhotic patients, being viral hepatitis and alcohol abuse, the main risk factors for its development. The introduction of highly sophisticated genomic technologies has spurred extensive research on the molecular pathogenesis of this devastating disease. Several signaling cascades have been consistently found dysregulated in HCC (e.g., WNT-beta-catenin, PI3K/AKT/MTOR, RAS/MAPK, IGF, HGF/MET, VEGF, EGFR, and PDGF). In addition, there have been numerous molecular classifications proposed for this disease, what provides an additional hint about its genomic complexity. The importance of knowing the molecular drivers of HCC is underscored by the positive results of a molecular targeted agent, sorafenib, able to improve survival in patients with advanced disease. This review will briefly outline key concepts in alcohol-related hepatocarcinogenesis, and provide some insight regarding current trends in translating HCC genomics into clinical management of the disease.

引用

页码：821 / 825

页数：5

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