Synthesis of substituted 2-ethoxycarbonyl- and 2-carboxyquinoxalin-3-ones for evaluation of antimicrobial and anticancer activity

被引：48

作者：

Sanna, P

Carta, A

Loriga, M

Zanetti, S

Sechi, L

机构：

[1] Ist Chim Farmaceut & Tossicol, I-07100 Sassari, Italy

[2] Dipartimento Sci Biomed, I-07100 Sassari, Italy

来源：

FARMACO | 1998年 / 53卷 / 07期

关键词：

quinoxalinones; antimicrobial activity; anticancer activity;

D O I：

10.1016/S0014-827X(98)00044-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A series of variously substituted quinoxalin-3-ones bearing an ethoxycarbonyl or carboxy group in the C-2 position has been prepared and their structures proved by H-1 NMR spectroscopy. The obtained compounds were investigated in vitro for antimicrobial and anticancer activities. Preliminary results showed a moderate activity against a few strains of bacteria but no significant anticancer and anti-HIV activity. (C) 1998 Elsevier Science S.A. All rights reserved.

引用

页码：455 / 461

页数：7

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