Micronuclei and other nuclear lesions as genotoxicity indicators in rainbow trout Oncorhynchus mykiss

被引：76

作者：

Ayllón, F ^{[1
]}

Garcia-Vazquez, E ^{[1
]}

机构：

[1] Univ Oviedo, Fac Med, Dept Biol Func, Area Genet, E-33006 Oviedo, Spain

来源：

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | 2001年 / 49卷 / 03期

关键词：

genotoxicity; micronuclei; nuclear abnormalities; Oncorhynchus mykiss;

D O I：

10.1006/eesa.2001.2065

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The induction of micronuclei and other nuclear abnormalities in renal erythrocytes of rainbow trout Oncorhynchus mykiss by six genotoxic compounds is evaluated, Colchicine, mitomycin cyclophosphamide, acrylamide, methyl-methanesulfonate, and N-ethyl-N-nitrosourea were intraperitoneally injected in trout. Our results show that cyclophosphamide induces the formation of micronuclei and also the other nuclear abnormalities; N-ethyl-N-nitrosourea, acrylamide, and colchicine induce only micronuclei; mitomycin-C induces only other nuclear abnormalities but not micronuclei, Methyl-methanesulfonate does not induce nuclear abnormalities in rainbow trout at the dose assayed in this work. The possible genotoxic origin for the different nuclear abnormalities is discussed. (C) 2001 Academic Press.

引用

页码：221 / 225

页数：5

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