Stillbirths 5 Stillbirths: the way forward in high-income countries

被引:334
作者
Flenady, Vicki [1 ,2 ,3 ]
Middleton, Philippa [4 ]
Smith, Gordon C. [5 ]
Duke, Wes [6 ]
Erwich, Jan Jaap [7 ,8 ]
Khong, T. Yee [9 ]
Neilson, Jim [10 ]
Ezzati, Majid [11 ]
Koopmans, Laura
Ellwood, David [12 ,13 ]
Fretts, Ruth [14 ]
Froen, J. Frederik [15 ]
机构
[1] Mater Med Res Inst, Mater Hlth Serv, Brisbane, Qld 4101, Australia
[2] Univ Queensland, Brisbane, Qld, Australia
[3] Int Stillbirth Alliance, Baltimore, MD USA
[4] Univ Adelaide, Adelaide, SA, Australia
[5] Univ Cambridge, Dept Obstet & Gynaecol, Cambridge, England
[6] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA
[7] Univ Groningen, Dept Obstet, Utrecht, Netherlands
[8] Fdn Perinatal Audit Netherlands, Utrecht, Netherlands
[9] Womens & Childrens Hosp, SA Pathol, Adelaide, SA, Australia
[10] Univ Liverpool, Cochrane Pregnancy & Childbirth Grp, Liverpool L69 3BX, Merseyside, England
[11] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, MRC HPA Ctr Environm & Hlth, London, England
[12] Canberra Hosp, Canberra, ACT, Australia
[13] Australian Natl Univ, Sch Med, Canberra, ACT, Australia
[14] Harvard Vanguard Med Associates, Wellesley, MA USA
[15] Norwegian Inst Publ Hlth, Div Epidemiol, Oslo, Norway
基金
比尔及梅琳达.盖茨基金会;
关键词
PERINATAL-MORTALITY; GESTATIONAL-AGE; FETAL-DEATH; PERIODONTAL-DISEASE; AVOIDABLE MORTALITY; ALCOHOL-CONSUMPTION; NEONATAL DEATHS; AUTOPSY RATES; PRENATAL-CARE; BIRTH-WEIGHT;
D O I
10.1016/S0140-6736(11)60064-0
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Stillbirth rates in high-income countries declined dramatically from about 1940, but this decline has slowed or stalled over recent times. The present variation in stillbirth rates across and within high-income countries indicates that further reduction in stillbirth is possible. Large disparities (linked to disadvantage such as poverty) in stillbirth rates need to be addressed by providing more educational opportunities and improving living conditions for women. Placental pathologies and infection associated with preterm birth are linked to a substantial proportion of stillbirths. The proportion of unexplained stillbirths associated with under investigation continues to impede efforts in stillbirth prevention. Overweight, obesity, and smoking are important modifiable risk factors for stillbirth, and advanced maternal age is also an increasingly prevalent risk factor. Intensified efforts are needed to ameliorate the effects of these factors on stillbirth rates. Culturally appropriate preconception care and quality antenatal care that is accessible to all women has the potential to reduce stillbirth rates in high-income countries. Implementation of national perinatal mortality audit programmes aimed at improving the quality of care could substantially reduce stillbirths. Better data on numbers and causes of stillbirth are needed, and international consensus on definition and classification related to stillbirth is a priority. All parents should be offered a thorough investigation including a high-quality autopsy and placental histopathology. Parent organisations are powerful change agents and could have an important role in raising awareness to prevent stillbirth. Future research must focus on screening and interventions to reduce antepartum stillbirth as a result of placental dysfunction. Identification of ways to reduce maternal overweight and obesity is a high priority for high-income countries.
引用
收藏
页码:1703 / 1717
页数:15
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