A second chance for hormone replacement therapy? Hormone replacement therapy for older women has been vilified after two major studies showed that it increased their susceptibility to various diseases. But scientists maintain that, used differently, it can still help to protect against neurological and cardiovascular diseases

被引：6

作者：

Brower, V

机构：

来源：

EMBO REPORTS | 2003年 / 4卷 / 12期

关键词：

D O I：

10.1038/sj.embor.7400043

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：1112 / 1115

页数：5

共 12 条

[1] Effects of estrogen plus progestin on gynecologic cancers and associated diagnostic procedures - The Women's Health Initiative randomized trial [J].

Anderson, GL ;

Judd, HL ;

Kaunitz, AM ;

Barad, DH ;

Beresford, SAA ;

Pettinger, M ;

Liu, J ;

McNeeley, SG ;

Lopez, AM .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 290 (13) :1739-1748

[2]

Beral Valerie, 2003, Lancet, V362, P419, DOI 10.1016/S0140-6736(03)14065-2

[3] Effects of estrogen plus progestin on risk of fracture and bone mineral density - The Women's Health Initiative randomized trial [J].

Cauley, JA ;

Robbins, J ;

Chen, Z ;

Cummings, SR ;

Jackson, RD ;

LaCroix, AZ ;

LeBoff, M ;

Lewis, CE ;

McGowan, J ;

Neuner, J ;

Pettinger, M ;

Stefanick, ML ;

Wactawski-Wende, J ;

Watts, NB .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 290 (13) :1729-1738

[4] Postmenopausal estrogen and progestin use and the risk of cardiovascular disease [J].

Grodstein, F ;

Stampfer, MJ ;

Manson, JE ;

Colditz, GA ;

Willett, WC ;

Rosner, B ;

Speizer, FE ;

Hennekens, CH .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (07) :453-461

[5] Changes in use of hormone replacement therapy after the report from the Women's Health Initiative: cross sectional survey of users [J].

Lawton, B ;

Rose, S ;

McLeod, D ;

Dowell, A .

BRITISH MEDICAL JOURNAL, 2003, 327 (7419) :845-846

[6] Divergent impact of progesterone and medroxyprogesterone acetate (Provera) on nuclear mitogen-activated protein kinase signaling [J].

Nilsen, J ;

Brinton, RD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (18) :10506-10511

[7] Impact of progestins on estradiol potentiation of the glutamate calcium response [J].

Nilsen, J ;

Brinton, RD .

NEUROREPORT, 2002, 13 (06) :825-830

[8] Impact of progestins on estrogen-induced neuroprotection: Synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetate [J].

Nilsen, J ;

Brinton, RD .

ENDOCRINOLOGY, 2002, 143 (01) :205-212

[9] Effect of estrogen plus progestin on global cognitive function in postmenopausal women - The Women's Health Initiative Memory Study: A randomized controlled trial [J].

Rapp, SR ;

Espeland, MA ;

Shumaker, SA ;

Henderson, VW ;

Brunner, RL ;

Manson, JE ;

Gass, MLS ;

Stefanick, ML ;

Lane, DS ;

Hays, J ;

Johnson, KC ;

Coker, LH ;

Dailey, M ;

Bowen, D .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 289 (20) :2663-2672

[10] Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women - The Women's Health Initiative Memory Study: A randomized controlled trial [J].

Shumaker, SA ;

Legault, C ;

Rapp, SR ;

Thal, L ;

Wallace, RB ;

Ockene, JK ;

Hendrix, SL ;

Jones, BN ;

Assaf, AR ;

Jackson, RD ;

Kotchen, JM ;

Wassertheil-Smoller, S ;

Wactawski-Wende, J .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 289 (20) :2651-2662

← 1 2 →