BDNF and NT-4, but not NT-3, promote development of inhibitory synapses in the absence of neuronal activity

被引：34

作者：

Seil, FJ ^{[1
]}

机构：

[1] Vet Adm Med Ctr, Neurol Res 151N, Portland, OR 97201 USA

[2] Oregon Hlth Sci Univ, Dept Neurol, Portland, OR 97201 USA

[3] Oregon Hlth Sci Univ, Dept Dev & Cell Biol, Portland, OR 97201 USA

来源：

BRAIN RESEARCH | 1999年 / 818卷 / 02期

关键词：

neurotrophin; cerebellar culture; Purkinje cell; synaptogenesis; activity-dependent plasticity;

D O I：

10.1016/S0006-8993(98)01304-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Development of the full complement of inhibitory synapses in cerebellar cultures requires the presence of neuronal activity. The neurotrophins, BDNF, NT-3 and NT-4, were applied to cerebellar explants during activity blockade. Control numbers of inhibitory Purkinje cell axosomatic synapses developed in the presence of the TrkB receptor ligands, BDNF and NT-4, but not the TrkC receptor ligand, NT-3. The results suggest that BDNF and NT-4 have a role in the promotion of activity-dependent inhibitory synaptogenesis. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：561 / 564

页数：4

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