The interplay between Mad and Myc in proliferation and differentiation

被引：53

作者：

Zhou, ZQ

Hurlin, PJ

机构：

[1] Oregon Hlth Sci Univ, Shriners Hosp Children, Portland, OR 97201 USA

[2] Oregon Hlth Sci Univ, Dept Cell & Dev Biol, Portland, OR 97201 USA

来源：

TRENDS IN CELL BIOLOGY | 2001年 / 11卷 / 11期

关键词：

D O I：

10.1016/S0962-8924(01)82037-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Members of the Myc family of transcription factors are key regulators of cell proliferation, and excessive levels of Myc lead to tumor formation. Mad family proteins are related to Myc, but they antagonize the oncogenic activity of Myc in cell-culture assays. Here, we examine current models of Mad function and the relationship between Mad and Myc in cell proliferation, differentiation and tumorigenesis.

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页码：S10 / S14

页数：5

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