Elimination diet in cow's milk allergy:: Risk for impaired growth in young children

被引:180
作者
Isolauri, E [1 ]
Sütas, Y
Salo, MK
Isosomppi, R
Kaila, M
机构
[1] Univ Turku, Dept Pediat, FIN-20520 Turku, Finland
[2] Univ Tampere, Sch Med, FIN-33101 Tampere, Finland
基金
芬兰科学院;
关键词
D O I
10.1016/S0022-3476(98)70399-3
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective: The objective of this study was to evaluate the nutritional impact of therapeutic elimination diets and to identify risk factors predisposing infants with food allergy to poor growth. Study design: We studied 100 children (mean age 7 months) with atopic dermatitis and challenge-proven cow's milk allergy and evaluated their growth during the symptomatic period before diagnosis and during the therapeutic elimination diet. Results: Clinical control of symptoms was achieved in all patients. The mean length SD score and weight-for-length index of patients decreased compared with those in healthy age-matched children, p < 0.0001 and p = 0.03, respectively. Low serum albumin was present in 6% of the patients, 24% had an abnormal urea concentration, and 8% had a low serum phospholipid docosahexaenoic acid. The delay in growth was more pronounced in a subgroup of patients with early onset than in those with later of symptoms (F = 6.65, p < 0.0001). The duration of breast-feeding correlated positively with the sum of n-3 polyunsaturated fatty acids (r = 0.39, p = 0.001) and with the relative amount of docosahexaenoic acid (r = 0.36, p = 0.002). Conclusion: A delicate balance exists between the benefits and the risks of elimination diets.
引用
收藏
页码:1004 / 1009
页数:6
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