Dysfunctional cortico-cerebellar circuits cause 'cognitive dysmetria' in schizophrenia

被引：95

作者：

Wiser, AK ^{[1
]}

Andreasen, NC ^{[1
]}

O'Leary, DS ^{[1
]}

Watkins, GL ^{[1
]}

Ponto, LLB ^{[1
]}

Hichwa, RD ^{[1
]}

机构：

[1] Univ Iowa, Coll Med, Mental Hlth Clin Res Ctr, Iowa City, IA 52242 USA

来源：

NEUROREPORT | 1998年 / 9卷 / 08期

关键词：

cerebellum; frontal cortex; memory; PET; recognition; schizophrenia; word;

D O I：

10.1097/00001756-199806010-00042

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

WE examined regional cerebral blood flow (rCBF) during a long-term recognition memory task for words in schizophrenic patients and in healthy subjects using positron emission tomography (PET). The task was designed so that performance scores were similar in the patient and control subjects. This memory retrieval task did not increase rCBF in the patients' prefrontal cortex, precuneus and cerebellum as much as it did in the control group. These results point to a dysfunctional corticocerebellar circuit leading to poorly coordinated mental activity ('cognitive dysmetria'), which could explain the broad range of schizophrenic symptoms. In addition, other brain areas were more activated by the task in the patient group than in the control group and may form a compensatory network performing the memory retrieval task by assisting or replacing the dysfunctional cortico-cerebellar circuit. (C) 1998 Rapid Science Ltd.

引用

页码：1895 / 1899

页数：5

共 25 条

[1] A NEW ROLE FOR THE CEREBELLUM IN COGNITIVE OPERATIONS [J].

AKSHOOMOFF, NA ;

COURCHESNE, E .

BEHAVIORAL NEUROSCIENCE, 1992, 106 (05) :731-738

[2] Schizophrenia and cognitive dysmetria: A positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry [J].

Andreasen, NC ;

OLeary, DS ;

Cizadlo, T ;

Arndt, S ;

Rezai, K ;

Ponto, LLB ;

Watkins, GL ;

Hichwa, RD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (18) :9985-9990

[3]

ANDREASEN NC, 1992, ARCH GEN PSYCHIAT, V49, P943

[4] Hypofrontality in schizophrenia: Distributed dysfunctional circuits in neuroleptic-naive patients [J].

Andreasen, NC ;

OLeary, DS ;

Flaum, M ;

Nopoulos, P ;

Watkins, GL ;

Ponto, LLB ;

Hichwa, RD .

LANCET, 1997, 349 (9067) :1730-1734

[5] SHORT-TERM AND LONG-TERM VERBAL MEMORY - A POSITRON EMISSION TOMOGRAPHY STUDY [J].

ANDREASEN, NC ;

OLEARY, DS ;

ARNDT, S ;

CIZADLO, T ;

HURTIG, R ;

REZAI, K ;

WATKINS, GL ;

PONTO, LLB ;

HICHWA, RD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (11) :5111-5115

[6] Tests for comparing images based on randomization and permutation methods [J].

Arndt, S ;

Cizadlo, T ;

Andreasen, NC ;

Heckel, D ;

Gold, S ;

OLeary, DS .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1996, 16 (06) :1271-1279

[7]

BERMAN KF, 1986, ARCH GEN PSYCHIAT, V43, P126

[8] GLUCOSE METABOLIC-RATE IN NORMALS AND SCHIZOPHRENICS DURING THE CONTINUOUS PERFORMANCE-TEST ASSESSED BY POSITRON EMISSION TOMOGRAPHY [J].

BUCHSBAUM, MS ;

NUECHTERLEIN, KH ;

HAIER, RJ ;

WU, J ;

SICOTTE, N ;

HAZLETT, E ;

ASARNOW, R ;

POTKIN, S ;

GUICH, S .

BRITISH JOURNAL OF PSYCHIATRY, 1990, 156 :216-227

[9] INCREASED TEMPORAL-LOBE GLUCOSE USE IN CHRONIC-SCHIZOPHRENIC PATIENTS [J].

DELISI, LE ;

BUCHSBAUM, MS ;

HOLCOMB, HH ;

LANGSTON, KC ;

KING, AC ;

KESSLER, R ;

PICKAR, D ;

CARPENTER, WT ;

MORIHISA, JM ;

MARGOLIN, R ;

WEINBERGER, DR .

BIOLOGICAL PSYCHIATRY, 1989, 25 (07) :835-851

[10] Brain activity during memory retrieval - The influence of imagery and semantic cueing [J].

Fletcher, PC ;

Shallice, T ;

Frith, CD ;

Frackowiak, RSJ ;

Dolan, RJ .

BRAIN, 1996, 119 :1587-1596

← 1 2 3 →