Effect of shear stress on vascular inflammation and plaque development

被引：69

作者：

Helderman, Frank

Segers, Dolf

de Crom, Rini

Hierck, Berend P.

Poelmann, Rob E.

Evans, Paul C.

Krams, Rob

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Bioengn, London SW7 2A2, England

[2] Univ London Imperial Coll Sci Technol & Med, BHF Cardiovasc Sci Unit, Natl Heart & Lung Inst, London, England

[3] Leiden Univ, Med Ctr, Dept Anat & Embryol, NL-2300 RA Leiden, Netherlands

[4] Erasmus MC, Dept Cell Biol, Rotterdam, Netherlands

[5] Free Univ Amsterdam, Dept Phys, Rotterdam, Netherlands

来源：

CURRENT OPINION IN LIPIDOLOGY | 2007年 / 18卷 / 05期

关键词：

advanced atherosclerosis; shear stress; vulnerable plaque;

D O I：

10.1097/MOL.0b013e3282ef7716

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Shear stress has been shown to play a role in plaque induction, plaque progression and plaque rupture. The mechanism for plaque induction seems to differ from the role of shear stress for plaque rupture, whereby the former mechanism is induced by low shear stress and the latter by high shear stress.

引用

收藏

页码：527 / 533

页数：7

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