The Arabidopsis circadian clock incorporates a cADPR-based feedback loop

被引：169

作者：

Dodd, Antony N.

Gardner, Michael J.

Hotta, Carlos T.

Hubbard, Katharine E.

Dalchau, Neil

Love, John

Assie, Jean-Maurice

Robertson, Fiona C.

Jakobsen, Mia Kyed

Goncalves, Jorge

Sanders, Dale

Webb, Alex A. R.

机构：

[1] Univ Cambridge, Dept Plant Sci, Cambridge CB2 3EA, England

[2] Univ Cambridge, Dept Engn, Cambridge CB2 1PZ, England

[3] Univ York, Dept Biol, York YO10 5YW, N Yorkshire, England

来源：

SCIENCE | 2007年 / 318卷 / 5857期

基金：

英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;

关键词：

D O I：

10.1126/science.1146757

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Transcriptional feedback loops are a feature of circadian clocks in both animals and plants. We show that the plant circadian clock also incorporates the cytosolic signaling molecule cyclic adenosine diphosphate ribose (cADPR). cADPR modulates the circadian oscillator's transcriptional feedback loops and drives circadian oscillations of Ca2+ release. The effects of antagonists of cADPR signaling, manipulation of cADPR synthesis, and mathematical simulation of the interaction of cADPR with the circadian clock indicate that cADPR forms a feedback loop within the plant circadian clock.

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收藏

页码：1789 / 1792

页数：4

相关论文

共 22 条

[1] Reciprocal regulation between TOC1 and LHY/CCA1 within the Arabidopsis circadian clock [J].

Alabadí, D ;

Oyama, T ;

Yanovsky, MJ ;

Harmon, FG ;

Más, P ;

Kay, SA .

SCIENCE, 2001, 293 (5531) :880-883

[2] RELEASE OF CA2+ FROM INDIVIDUAL PLANT VACUOLES BY BOTH INSP(3) AND CYCLIC ADP-RIBOSE [J].

ALLEN, GJ ;

MUIR, SR ;

SANDERS, D .

SCIENCE, 1995, 268 (5211) :735-737

[3] Plant circadian clocks increase photosynthesis, growth, survival, and competitive advantage [J].

Dodd, AN ;

Salathia, N ;

Hall, A ;

Kévei, E ;

Tóth, R ;

Nagy, F ;

Hibberd, JM ;

Millar, AJ ;

Webb, AAR .

SCIENCE, 2005, 309 (5734) :630-633

[4] FLOWERING LOCUS C mediates natural variation in the high-temperature response of the Arabidopsis circadian clock [J].

Edwards, KD ;

Anderson, PE ;

Hall, A ;

Salathia, NS ;

Locke, JCW ;

Lynn, JR ;

Straume, M ;

Smith, JQ ;

Millar, AJ .

PLANT CELL, 2006, 18 (03) :639-650

[5]

GRAEFF RM, 1994, J BIOL CHEM, V269, P30260

[6] Circadian rhythms confer a higher level of fitness to Arabidopsis plants [J].

Green, RM ;

Tingay, S ;

Wang, ZY ;

Tobin, EM .

PLANT PHYSIOLOGY, 2002, 129 (02) :576-584

[7] Orchestrated transcription of key pathways in Arabidopsis by the circadian clock [J].

Harmer, SL ;

Hogenesch, LB ;

Straume, M ;

Chang, HS ;

Han, B ;

Zhu, T ;

Wang, X ;

Kreps, JA ;

Kay, SA .

SCIENCE, 2000, 290 (5499) :2110-2113

[8] Circadian dynamics of cytosolic and nuclear Ca2+ in single suprachiasmatic nucleus neurons [J].

Ikeda, M ;

Sugiyama, T ;

Wallace, CS ;

Gompf, HS ;

Yoshioka, T ;

Miyawaki, A ;

Allen, CN .

NEURON, 2003, 38 (02) :253-263

[9] CIRCADIAN OSCILLATIONS OF CYTOSOLIC AND CHLOROPLASTIC FREE CALCIUM IN PLANTS [J].

JOHNSON, CH ;

KNIGHT, MR ;

KONDO, T ;

MASSON, P ;

SEDBROOK, J ;

HALEY, A ;

TREWAVAS, A .

SCIENCE, 1995, 269 (5232) :1863-1865

[10] Extension of a genetic network model by iterative experimentation and mathematical analysis [J].

Locke, James C. W. ;

Southern, Megan M. ;

Kozma-Bognar, Laszlo ;

Hibberd, Victoria ;

Brown, Paul E. ;

Turner, Matthew S. ;

Millar, Andrew J. .

MOLECULAR SYSTEMS BIOLOGY, 2005, 1 (1) :2005.0013