Enlarged Substantia Nigra Hyperechogenicity and Risk for Parkinson Disease A 37-Month 3-Center Study of 1847 Older Persons

被引：117

作者：

Berg, Daniela ^{[1
,2
]}

Seppi, Klaus ^{[3
]}

Behnke, Stefanie ^{[4
]}

Liepelt, Inga ^{[1
,2
]}

Schweitzer, Katherine ^{[1
]}

Stockner, Heike ^{[3
]}

Wollenweber, Frank ^{[4
]}

Gaenslen, Alexandra ^{[1
,2
]}

Mahlknecht, Philipp ^{[3
]}

Spiegel, Joerg ^{[4
]}

Godau, Jana ^{[1
,2
]}

Huber, Heiko ^{[1
,2
]}

Srulijes, Karin ^{[1
,2
]}

Kiechl, Stefan ^{[3
]}

Bentele, Marianna

Gasperi, Arno ^{[5
]}

Schubert, Teresa

Hiry, Teresa

Probst, Mareike

Schneider, Vera

Klenk, Jochen ^{[6
]}

Sawires, Martin ^{[3
]}

Willeit, Johann ^{[3
]}

Maetzler, Walter ^{[1
,2
,6
]}

Fassbender, Klaus ^{[4
]}

Gasser, Thomas ^{[1
,2
]}

Poewe, Werner ^{[3
]}

机构：

[1] Hertie Inst Clin Brain Res, Dept Neurodegenerat, D-72076 Tubingen, Germany

[2] German Ctr Neurodegenerat Dis, D-72076 Tubingen, Germany

[3] Univ Innsbruck, Dept Neurol, A-6020 Innsbruck, Austria

[4] Univ Homburg Saar, Dept Neurol, Homburg, Germany

[5] Bruneck Hosp, Dept Neurol, Brunico, Italy

[6] Robert Bosch Krankenhaus, Dept Geriatr Rehabil, Stuttgart, Germany

来源：

ARCHIVES OF NEUROLOGY | 2011年 / 68卷 / 07期

关键词：

SONOGRAPHIC DISCRIMINATION; TRANSCRANIAL SONOGRAPHY; MOVEMENT-DISORDERS; ULTRASOUND; DEGENERATION; ASSOCIATION; DYSFUNCTION; PREVALENCE; DIAGNOSIS; DEMENTIA;

D O I：

10.1001/archneurol.2011.141

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To evaluate whether enlarged substantia nigra hyperechogenicity (SN+) is associated with an increased risk for Parkinson disease (PD) in a healthy elderly population. Design: Longitudinal 3-center observational study with 37 months of prospective follow-up. Setting: Individuals 50 years or older without evidence of PD or any other neurodegenerative disease. Participants: Of 1847 participants who underwent a full medical history, neurological assessment, and transcranial sonography at baseline, 1535 could undergo reassessment. Main Outcome Measure: Incidence of new-onset PD in relation to baseline transcranial sonography status. Results: There were 11 cases of incident PD during the follow-up period. In participants with SN+ at baseline, the relative risk for incident PD was 17.37 (95% confidence interval, 3.71-81.34) times higher compared with normoechogenic participants. Conclusions: In this prospective study, we demonstrate for the first time a highly increased risk for PD in elderly individuals with SN+. Transcranial sonography of the midbrain may therefore be a promising primary screening procedure to define a risk population for imminent PD.

引用

页码：932 / 937

页数：6

共 30 条

[1] DEGENERATION OF SUBSTANTIA-NIGRA IN CHRONIC PARKINSONS-DISEASE VISUALIZED BY TRANSCRANIAL COLOR-CODED REAL-TIME SONOGRAPHY [J].