A parallel combinatorial approach to locating homochiral Lewis acid catalysts for the asymmetric aza-Diels-Alder reaction of an imino dienophile.

被引：97

作者：

Bromidge, S

Wilson, PC

Whiting, A ^{[1
]}

机构：

[1] SmithKline Beecham Pharmaceut, Harlow CM19 5AD, Essex, England

[2] Univ Manchester, Inst Sci & Technol, Dept Chem, Manchester M60 1QD, Lancs, England

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 48期

关键词：

D O I：

10.1016/S0040-4039(98)01947-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New catalytic asymmetric Lewis acids have been developed for the aza-Diels-Alder reaction of a methyl glyoxalate and p-anisidine derived imine with Danishefsky's diene. The catalysts were developed using parallel combinatorial methods with the highest e.e, being 97 % using (1S, 2S)-1,2-diphenylthylenediamine and magnesium iodide in acetanitrile. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：8905 / 8908

页数：4

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