Neuroinflammation and the genetics of Alzheimer's disease:: The search for a pro-inflammatory phenotype

被引：74

作者：

Franceschi, C ^{[1
]}

Valensin, S ^{[1
]}

Lescai, F ^{[1
]}

Olivieri, F ^{[1
]}

Licastro, F ^{[1
]}

Grimaldi, LME ^{[1
]}

Monti, D ^{[1
]}

De Benedictis, G ^{[1
]}

Bonafè, M ^{[1
]}

机构：

[1] Univ Bologna, Dept Expt Pathol, I-40125 Bologna, Italy

来源：

AGING-CLINICAL AND EXPERIMENTAL RESEARCH | 2001年 / 13卷 / 03期

关键词：

aging; Alzheimer's disease; genetics of AD; inflamm-aging; neuroinflammation; pro-inflammatory phenotype;

D O I：

10.1007/BF03351475

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The role of interleukin 1 (IL-1) and in terleukin 6 (IL-6) in the pathogenesis of Alzheimer's disease (AD) is reviewed within the framework of "inflamm-aging", i.e., the characteristic chronic pro-inflammmatory status which develops in old age, and neuroinflammation, i.e., the peculiar inflammatory process which is present in the brain of AD patients. In particular, the data suggesting that several IL-1 and IL-6 gene polymorphisms can contribute to the risk of developing AD are reviewed. The possibility as well as the difficulty in identifying a pro-inflammmatory phenotype, and its importance for the prevention, diagnosis and therapy of AD and other age-related pathologies are discussed. (C) 2001, Editrice Kurtis.

引用

页码：163 / 170

页数：8

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