Increased levels of HIV-1-infected cells in endocervical secretions after the luteinizing hormone surge

被引：7

作者：

Benki, Sarah ^{[1
,2
]}

Mostad, Sara B. ^{[3
,4
]}

Richardson, Barbra A. ^{[5
]}

Mandaliya, Kishorchandra ^{[6
]}

Kreiss, Joan K. ^{[3
,4
]}

Overbaugh, Julie ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA

[2] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA

[3] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

[4] Univ Washington, Dept Med, Seattle, WA USA

[5] Univ Washington, Dept Biostat, Seattle, WA 98195 USA

[6] Coast Provincial Hosp, Mombasa, Kenya

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2008年 / 47卷 / 05期

关键词：

cervical; genital shedding; HIV-1; DNA; hormones; infectivity;

D O I：

10.1097/QAI.0b013e318165b952

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Levels of HIV-1 RNA in endocervical specimens fluctuate with the menstrual cycle, suggesting that cell-free HIV-1 levels may vary during the cycle, which could influence infectivity. Here, we examined daily changes in endocervical HIV-1-infected cells during I cycle. There were significant positive associations between the number of days from the luteinizing hormone surge and the number of HIV-1 DNA copies/swab (P = 0.001) and the number of total cells/swab (P < 0.001) in endocervical specimens. These data suggest that sampling of cell-associated endocervical HIV-1 increases after the periovulatory period, which could result in increased exposure to HIV-1-infected cells during sexual contact.

引用

页码：529 / 534

页数：6

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