Aging and cancer cell biology, 2008

被引:38
作者
Campisi, Judith [1 ,2 ]
机构
[1] Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA
[2] Inst Age Res, Novato, CA 94945 USA
关键词
apoptosis; cellular senescence; DNA damage; DNA repair; longevity; p53; telomeres; tumor suppression;
D O I
10.1111/j.1474-9726.2008.00383.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
There is increasing support for the idea that aging and cancer are intimately connected by the activity of specific genes and the cellular responses to potentially oncogenic insults. This Hot Topics review discusses some recently published articles that shed light on both the commonalities - and intricacies - of the cancer-aging relationship. These articles reveal the expected complexities, but also surprising conservation, in mechanisms that link cancer and aging.
引用
收藏
页码:281 / 284
页数:4
相关论文
共 28 条
[1]  
ARUM O, 2001, J GERONTOL, V62, P951
[2]   Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span [J].
Bauer, JH ;
Poon, PC ;
Glatt-Deeley, H ;
Abrams, JM ;
Helfand, SL .
CURRENT BIOLOGY, 2005, 15 (22) :2063-2068
[3]  
Benz Christopher C, 2007, Cancer Res, V67, P4560, DOI 10.1158/0008-5472.CAN-07-1236
[4]   Drosophila p53 binds a damage response element at the reaper locus [J].
Brodsky, MH ;
Nordstrom, W ;
Tsang, G ;
Kwan, E ;
Rubin, GM ;
Abrams, JM .
CELL, 2000, 101 (01) :103-113
[5]   Cancer and ageing: Rival demons? [J].
Campisi, J .
NATURE REVIEWS CANCER, 2003, 3 (05) :339-349
[6]   LMNA mutations in atypical Werner's syndrome [J].
Chen, LS ;
Lee, L ;
Kudlow, BA ;
Dos Santos, HG ;
Sletvold, O ;
Shafeghati, Y ;
Botha, EG ;
Garg, A ;
Hanson, NB ;
Martin, GM ;
Mian, IS ;
Kennedy, BK ;
Oshima, J .
LANCET, 2003, 362 (9382) :440-445
[7]   p53 protein variants: structural and functional similarities with p63 and p73 isoforms [J].
Courtois, S ;
de Fromentel, CC ;
Hainaut, P .
ONCOGENE, 2004, 23 (03) :631-638
[8]   Caenorhabditis elegans p53:: Role in apoptosis, meiosis, and stress resistance [J].
Derry, WB ;
Putzke, AP ;
Rothman, JH .
SCIENCE, 2001, 294 (5542) :591-595
[9]  
EDWARDS MG, 2007, BMC GENOMICS, V8
[10]   Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome [J].
Eriksson, M ;
Brown, WT ;
Gordon, LB ;
Glynn, MW ;
Singer, J ;
Scott, L ;
Erdos, MR ;
Robbins, CM ;
Moses, TY ;
Berglund, P ;
Dutra, A ;
Pak, E ;
Durkin, S ;
Csoka, AB ;
Boehnke, M ;
Glover, TW ;
Collins, FS .
NATURE, 2003, 423 (6937) :293-298