Prognostic significance of c-erbB-2 protein expression in carcinoma of the cervix treated with radiotherapy

被引:20
作者
Nishioka, T
West, CML
Gupta, N
Wilks, DP
Hendry, JH
Davidson, SE
Hunter, RD
机构
[1] Christie Hosp NHS Trust, Paterson Inst Canc Res, Dept Expt Radiat Oncol, Manchester M20 4BX, Lancs, England
[2] Christie Hosp NHS Trust, Dept Clin Oncol, Manchester M20 4BX, Lancs, England
关键词
cervix; radiation; c-erbB-2;
D O I
10.1007/s004320050248
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: The relationship was studied between c-erbB-2 expression and outcome in 107 carcinomas of the cervix treated with radical radiotherapy. Methods: Formalin-fixed, paraffin-embedded sections were stained by immunohistochemistry for over-expression of the c-erbB-2 protein. A retrospective study of treatment outcome was made on patients with a median follow-up of 55 months. Results: Patients with c-erbB-2-positive tumours had a significantly worse overall survival rate than those with c-erbB-2-negative tumours (P = 0.019). Metastasis-free survival (i.e. recurrence outside the radiotherapy field) was also significantly worse (P < 0.001) but there were no differences in local control (i.e. recurrence within the radiotherapy field) rates (P = 0.24). Bivariate log-rank analyses showed that the prognostic value of c-erbB-2 expression for metastasis-free survival was independent of disease stage, histological grade, patient age, tumour size and tumour radiosensitivity. A combination of two biological parameters yielded a high discrimination between outcome groups. Women with radiosensitive and c-er-bB-2-negative tumours had a 5-year metastasis-free survival level of 70% compared to 33% for women with radioresistant, c-erbB-2-positive tumours. Conclusions: c-erbB-2 expression is an important prognostic factor for determining tumour recurrence outside the treatment field in cervix carcinomas treated with radiotherapy.
引用
收藏
页码:96 / 100
页数:5
相关论文
共 20 条
[1]  
Altavilla G., 1996, European Journal of Gynaecological Oncology, V17, P267
[2]  
BACUS SS, 1994, AM J CLIN PATHOL, V102, pS13
[3]  
Costa MJ, 1995, AM J CLIN PATHOL, V104, P634
[4]   PROGNOSTIC FACTORS IN PATIENTS WITH CERVIX CANCER TREATED BY RADIATION-THERAPY - RESULTS OF A MULTIPLE-REGRESSION ANALYSIS [J].
FYLES, AW ;
PINTILIE, M ;
KIRKBRIDE, P ;
LEVIN, W ;
MANCHUL, LA ;
RAWLINGS, GA .
RADIOTHERAPY AND ONCOLOGY, 1995, 35 (02) :107-117
[5]   PROGNOSTIC VALUE OF C-ERBB-2 EXPRESSION IN UTERINE CERVICAL-CARCINOMA [J].
HALE, RJ ;
BUCKLEY, CH ;
FOX, H ;
WILLIAMS, J .
JOURNAL OF CLINICAL PATHOLOGY, 1992, 45 (07) :594-596
[6]  
Hockel M, 1996, CANCER RES, V56, P4509
[7]  
HUNTER RD, 1991, RADIOTHERAPY MALIGNA, P279
[8]  
KIHANA T, 1994, CANCER, V73, P148, DOI 10.1002/1097-0142(19940101)73:1<148::AID-CNCR2820730125>3.0.CO
[9]  
2-C
[10]  
KRISTENSEN GB, 1996, CANCER, V78, P443