Priming by DNA immunization augments protective efficacy of Mycobacterium bovis bacille Calmette-Guerin against tuberculosis

被引：105

作者：

Feng, CG

Palendira, U

Demangel, C

Spratt, JM

Malin, AS

Britton, WJ

机构：

[1] Centenary Inst Canc Med & Cell Biol, Newtown, NSW 2042, Australia

[2] Univ Sydney, Dept Med, Sydney, NSW 2006, Australia

[3] NIAID, Immunobiol Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA

[4] Inst Pasteur, Lab Ingn Anticorps, F-75724 Paris 15, France

[5] Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1E 7HT, England

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 06期

关键词：

D O I：

10.1128/IAI.69.6.4174-4176.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sequential immunization with mycobacterial antigen Ag85B-expressing DNA and Mycobacterium bovis bacille Calmette-Guerin (BCG) was more effective than BCG immunization in protecting against Mycobacterium tuberculosis infection. Depletion of the CD8(+) T cells in the immunized mice impaired protection in their spleens, indicating that this improved efficacy was partially mediated by CD8(+) T cells.

引用

收藏

页码：4174 / 4176

页数：3

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