Identification of a multixenobiotic resistance mechanism in Xenopus laevis embryos

被引：6

作者：

Bonfanti, P ^{[1
]}

Colombo, A ^{[1
]}

Camatini, M ^{[1
]}

机构：

[1] Univ Milan, Dipartimento Sci Ambiente & Terr, I-20126 Milan, Italy

来源：

CHEMOSPHERE | 1998年 / 37卷 / 14-15期

关键词：

multixenobiotic resistance mechanism (MXRM); Xenopus laevis; P-glycoprotein (Pgp);

D O I：

10.1016/S0045-6535(98)00318-X

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

In the '90's a membrane-associated transport protein, discovered in aquatic organisms, was considered to be expressed in response to environmental xenobiotics. Like the multidrug resistance protein found in mammalian tumor cell lines, this protein confers resistance in organisms in polluted areas by binding xenobiotics and transporting them out of the cells in an energy-dependent manner. This study investigates the expression and the activity of a P-glycoprotein (Pgp) involved in a multixenobiotic resistance mechanism (MXRM) during the early developmental stages and in tissues of adult Xenopus laevis. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2751 / 2760

页数：10

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[3]

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