BOLD signal sign and transient vessels volume variation

被引：4

作者：

Garreffa, G

Colonnese, C

Macrì, MA

Modugno, N

Rocca, R

Calistri, V

De Cesare, E

Venditti, E

Maraviglia, B ^{[1
]}

机构：

[1] Enrico Fermi Inst, Rome, Italy

[2] Ist Neurol Mediterraneo Neuromed, Pozzilli, IS, Italy

[3] Ist Nazl Fis Mat, UdR, Rome, Italy

[4] Univ Roma La Sapienza, Dipartimento Med Sperimentale & Patol, I-00185 Rome, Italy

[5] Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy

来源：

MAGNETIC RESONANCE IMAGING | 2003年 / 21卷 / 10期

关键词：

functional MRI (fMRI); apnea; venous blood volume;

D O I：

10.1016/j.mri.2003.08.022

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The purpose of this work was to investigate the relation between BOLD signal sign and transient vessels volume variation induced by apnea. This stimulus consisting of breath holding after inspiration is able to induce a light slowing down in venous blood flow like in a sort of Valsalva maneuver. We observed diffuse negative BOLD responding areas at cortical level and a stronger negative response in correspondence of the main sinuses. These phenomena seem to be unrelated to a specific neural activity, appearing to be expressions of a mechanical variation in the hemodynamics. Our study suggests that particular care must be considered in the interpretation of fMRI findings, especially when patients with vascular-related cerebral diseases are involved. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：1207 / 1212

页数：6

共 15 条

[1] Functional MRI cerebral activation and deactivation during finger movement [J].