The p75 neurotrophin receptor: multiple interactors and numerous functions

被引:136
作者
Gentry, JJ
Barker, PA
Carter, BD
机构
[1] Vanderbilt Univ, Sch Med, Dept Biochem, Nashville, TN 37232 USA
[2] Vanderbilt Univ, Sch Med, Ctr Mol Neurosci, Nashville, TN 37232 USA
[3] McGill Univ, Montreal Neurol Inst, Montreal, PQ H3A 2B4, Canada
来源
NGF AND RELATED MOLECULES IN HEALTH AND DISEASE | 2004年 / 146卷
关键词
NGF; p75 (NTR); NRIF; NRAGE; SC-1; NADE; apoptosis; TRAF;
D O I
10.1016/S0079-6123(03)46002-0
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The neurotrophin receptor p75 (p75(NTR)), is involved in a diverse array of cellular responses, including apoptosis, neurite outgrowth and myelination. Stimulation of p75(NTR) with neurotrophin can activate multiple downstream signals, including the small GTP binding protein Rac, the transcription factor NF-kappaB and the stress activated kinase, JNK. How these signals are generated and regulated to produce a specific cellular effect has yet to be fully elucidated. A number of proteins have recently been shown to interact with the intracellular domain of p75(NTR). Here, we review these p75(NTR) interacting factors and the current evidence as to how they contribute to the functional effects of p75(NTR) activation.
引用
收藏
页码:25 / 39
页数:15
相关论文
共 98 条
[1]   Attenuation of a caspase-3 dependent cell death in NT4-and p75-deficient embryonic sensory neurons [J].
Agerman, K ;
Baudet, C ;
Fundin, B ;
Willson, C ;
Ernfors, P .
MOLECULAR AND CELLULAR NEUROSCIENCE, 2000, 16 (03) :258-268
[2]   P53 is essential for developmental neuron death as regulated by the TrkA and p75 neurotrophin receptors [J].
Aloyz, RS ;
Bamji, SX ;
Pozniak, CD ;
Toma, JG ;
Atwal, J ;
Kaplan, DR ;
Miller, FD .
JOURNAL OF CELL BIOLOGY, 1998, 143 (06) :1691-1703
[3]   Gene encoding a new RING-B-box-Coiled-coil protein is mutated in mulibrey nanism [J].
Avela, K ;
Lipsanen-Nyman, M ;
Idänheimo, N ;
Seemanová, E ;
Rosengren, S ;
Mäkelä, TP ;
Perheentupa, J ;
de la Chapelle, A ;
Lehesjoki, AE .
NATURE GENETICS, 2000, 25 (03) :298-301
[4]   The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death [J].
Bamji, SX ;
Majdan, M ;
Pozniak, CD ;
Belliveau, DJ ;
Aloyz, R ;
Kohn, J ;
Causing, CG ;
Miller, FD .
JOURNAL OF CELL BIOLOGY, 1998, 140 (04) :911-923
[5]   Signal transduction by tumor necrosis factor and its relatives [J].
Baud, V ;
Karin, M .
TRENDS IN CELL BIOLOGY, 2001, 11 (09) :372-377
[6]   ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injury [J].
Beattie, MS ;
Harrington, AW ;
Lee, R ;
Kim, JY ;
Boyce, SL ;
Longo, FM ;
Bresnahan, JC ;
Hempstead, BL ;
Yoon, SO .
NEURON, 2002, 36 (03) :375-386
[7]  
Bentley CA, 2000, J NEUROSCI, V20, P7706
[8]   Strain-specific complementation between NRIF1 and NRIF2, two zinc finger proteins sharing structural and biochemical properties [J].
Benzel, I ;
Barde, YA ;
Casademunt, E .
GENE, 2001, 281 (1-2) :19-30
[9]   Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-κB activation [J].
Béraud, C ;
Henzel, WJ ;
Baeuerle, PA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (02) :429-434
[10]   EVIDENCE FOR PRO-BETA-NERVE GROWTH-FACTOR, A BIOSYNTHETIC PRECURSOR TO BETA-NERVE GROWTH-FACTOR - (ARGINYL-ESTEROPEPTIDASE-PROTEIN PROCESSING SUBMAXILLARY GLAND GAMMA-SUBUNIT EPIDERMAL GROWTH-FACTOR) [J].
BERGER, EA ;
SHOOTER, EM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (09) :3647-3651