Alcoholic liver disease: new insights into mechanisms and preventative strategies

被引：193

作者：

Stewart, S ^{[1
]}

Jones, D ^{[1
]}

Day, CP ^{[1
]}

机构：

[1] Med Sch Newcastle Upon Tyne, Dept Med, Liver Res Ctr, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

TRENDS IN MOLECULAR MEDICINE | 2001年 / 7卷 / 09期

关键词：

D O I：

10.1016/S1471-4914(01)02096-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Alcoholic liver disease has a known aetiology but a complex pathogenesis. It is an extremely common disease with a high mortality, but the reason why only a relatively small proportion of heavy drinkers progress to advanced disease remains elusive. Accumulating evidence points towards an elaborate interplay between metabolism, inflammation and immunity in the development of steatosis, hepatitis and fibrosis. These complex pathways leading to liver injury offer many potential susceptibility loci, as well as sites for potential therapeutic intervention.

引用

页码：408 / 413

页数：6

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